Amlodipine chemical structure
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Amlodipine

Amlodipine (as besylate or malleate) is a long-acting calcium channel blocker used as an anti-hypertensive and in the treatment of angina. Amlodipine is marketed as Norvasc® and under various other names. As other calcium channel blockers, amlodipine acts by relaxing the smooth muscle in the arterial wall, decreasing peripheral resistance and hence improving blood pressure; in angina it improves blood flow to the myocardium. It was developed under the direction of Dr. Simon Campbell. more...

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Side effects

Some side effects of the use of amlodipine may be:

  • Very often: peripheral edema (feet and ankles) - in 1 of 10 users
  • Often: dizzyness, palpitations, muscle, stomach or headache, dyspepsia, nausea - in 1 in 100 users
  • Sometimes: blood disorders, development of breasts in men (gynecomastia), impotence, depression, insomnia, tachycardia - in 1 in 1,000 users
  • Rarely: erratic behavior, hepatitis, jaundice - in 1 in 10,000 users
  • Very rarely: hyperglycemia, tremor, Stevens-Johnson syndrome - in 1 in 100,000 users

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Amlodipine for CAD and normal blood pressure
From American Family Physician, 3/15/05 by David Slawson

Clinical Question: Is the administration of amlodipine beneficial for patients with coronary artery disease (CAD) and normal blood pressure?

Setting: Outpatient (specialty)

Study Design: Randomized controlled trial (double-blinded)

Allocation: Uncertain

Synopsis: In this study, investigators enrolled 1,997 patients, 32 to 82 years of age, who had established CAD (i.e., greater than 20 percent coronary artery stenosis), and a diastolic blood pressure lower than 100 mm Hg, with or without treatment. They excluded patients with left main coronary artery obstruction greater than 50 percent, left ventricular ejection fraction less than 40 percent, or moderate to severe congestive heart failure. More than 75 percent of the participants were men, and nearly 90 percent were white. More than 60 percent had a history of hypertension, but less than one third currently were receiving a diuretic. Initial blood pressure measurement averaged 129/78 mm Hg for all patients.

After a two-week placebo run-in period to verify treatment compliance, participants were randomized in a double-blind fashion to receive amlodipine (10 mg per day), enalapril (20 mg per day), or placebo. Follow-up was complete for 24 months in more than 98 percent of the participants. Using intention-to-treat analysis, cardiovascular events occurred less often in patients receiving amlodipine (16.6 percent) and enalapril (20.2 percent) than in those taking placebo (23.1 percent). The difference was statistically significant only between the amlodipine and placebo groups (number needed to treat = 17; 95 percent confidence interval, 10.9 to 45.6).

Of the individual components of the composite end point of adverse cardiovascular events, only the need for revascularization and hospitalization for angina were statistically less in the amlodipine group. No differences existed among any of the groups in a reduction of nonfatal or fatal myocardial infarction (MI), cerebral vascular events, hospitalization for congestive heart failure, or all-cause mortality. All-causehospitalization rates were not reported. There were no significant differences between the amlodipine and enalapril groups. No significant differences were noted in the progression of atherosclerosis in the amlodipine and enalapril groups compared with the placebo group.

Bottom Line: The administration of amlodipine to patients with established CAD without evidence of left ventricular dysfunction and normal blood pressure, with or without treatment, may reduce the risk of coronary revascularization or hospitalization for recurrent chest pain. The current study does not show a clear benefit of amlodipine over placebo in reducing the risk of other patient-oriented outcomes, including MI, stroke,all-cause hospitalization, or death. Therefore, the investigators simply may be measuring the effects of amlodipine as an antianginal medication. (Level of Evidence: 1b-)

Study Reference: Nissen SE, et al. Effect of antihyperten-sive agents on cardiovascular events in patients with coronary disease and normal blood pressure: the CAMELOT study: a randomized controlled trial. JAMA November 10, 2004;292:2217-25.

Used with permission from Slawson D. Amlodipine for CAD and normal blood pressure minimally, if at all, beneficial (CAMELOT). Accessed online December 28, 2004, at: http://InfoPOEMs.com.

COPYRIGHT 2005 American Academy of Family Physicians
COPYRIGHT 2005 Gale Group

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