Minocycline chemical structure
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Arestin


Minocycline hydrochloride, also known as minocycline, is a member of the broad spectrum tetracycline antibiotics, and has a broader spectrum than the other members. As a result of its long half-life it generally has serum levels 2-4 times that of most other tetracyclines (150 mg giving 16 times the activity levels compared to 250 mg of tetracycline at 24-48 hours). more...

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It is marketed under several trade names, including Minomycin, Minocin, Arestin, and Dynacin.

Indications

It is primarily used to treat acne and rosacea as the once daily 100mg doasage is far easier for patients than the four times a day required with Tetracycline or Oxytetracycline.

Although minocycline's broader spectrum of activity, compared to other members of the group, includes activity against Neisseria meningitidis, its use as a prophylaxis is no longer recomended because of side effects (dizziness and vertigo).

Cautions and Side effects

In additon to those common to the Tetracycline antibiotics group, minocycline may be used in renal impairment, but may aggrevate systemic lupus erythematosus. ( and ).

Possible additional indications

Current research is examining the possible neuroprotective effects of minocycline against progression of Huntington's Disease, an inherited neurodegenerative disorder. (Research is summarized here and here.) The neuroprotective action of minocycline may include its inhibitory effect on 5-lipoxygenase , an inflammatory enzyme associated with brain aging .

Read more at Wikipedia.org


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Johnson & Johnson to buy OraPharma Inc. for 11.04 times revenue
From Weekly Corporate Growth Report, 11/18/02

The Deal: Johnson & Johnson has signed a definitive agreement to acquire OraPharma Inc. for $85 million. Under the terms of the agreement, OraPharma shareholders will receive $7.41 per share. The deal is expected to close in the first quarter of 2003, subject to customary closing conditions and regulatory approval.

Discussion: OraPharma is a development-stage company that researches treatments for dental diseases. The company's initial product, Arestin, is a treatment for periodontitis, a leading cause of adult tooth loss. The company is also developing a treatment for oral mucositis, a condition that occurs frequently in patients receiving chemotherapy or radiation therapy.

Johnson & Johnson is one of the world's largest, most diversified health care product makers. The company makes prescription pharmaceuticals, medical devices and diagnostic equipment, and consumer products ranging from bandages to toothbrushes. The company owns a number of famous brands, including Tylenol, Motrin, ACUVUE contact lenses, and Band-Aid. Johnson & Johnson has 197 operating companies in 54 countries around the world and sells products in over 175 countries.

The acquisition of OraPharma is intended to broaden Johnson & Johnson's portfolio of oral health products. The deal will provide OraPharma more resources to fully realize the potential of Arestin and other OraPharma products.

Copyright NVST, Inc. Nov 18, 2002
Provided by ProQuest Information and Learning Company. All rights Reserved

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