Chemical structure of Aspartic acidChemical structure of the amino acid aspartate
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Aspartic acid

Aspartic acid (Asp), also known as aspartate, the name of its anion, is one of the 20 natural proteinogenic amino acids which are the building blocks of proteins. more...

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As with each of the 20 natural amino acids, there are two abbreviations commonly used to designate aspartic acid: Asp (three letter) and D (one letter). The abbreviations signifying a choice of either aspartic acid or asparagine are Asx (three-letter) and B (one letter).

As its name indicates, aspartic acid is the carboxylic acid analog of asparagine. It is non-essential in mammals, and might serve as an excitatory neurotransmitter in the brain. It is also a metabolite in the urea cycle, and participates in gluconeogenesis.

As a neurotransmitter, aspartic acid may provide resistance to fatigue and thus lead to endurance, although the evidence to support this idea is not strong.

Notes and references

  1. ^  IUPAC-IUBMB Joint Commission on Biochemical Nomenclature. Nomenclature and Symbolism for Amino Acids and Peptides. Recommendations on Organic & Biochemical Nomenclature, Symbols & Terminology etc.. URL accessed on September 28, 2005.

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Vaccinations & Ascorbic Acid - Shorts - Brief Article
From Townsend Letter for Doctors and Patients, 2/1/02 by Jule Klotter

In his article "Vaccinations, Inoculations and Ascorbic Acid," C. Alan B. Clemetson, MD suggests that some of the severe reactions in infants after vaccination may be due to elevated histamine levels. Elevated histamine levels in tissue cause conditions such as hay fever, allergic rhinitis, and nettle-rash. Elevated blood histamine levels, however, cause convulsions, coma, and death. Experiments with guinea pigs have shown that the injection of vaccines or toxoids raise blood histamine levels.

Dr. Clemetson says that vitamin C supplementation reduces blood histamine levels by converting histamine to hydrantoin-5-acetic acid and then to aspartic acid. Supplementation also reduces mortality rates in animals and people who have received inoculations. Conversely, studies have shown that a deficiency of vitamin C made guinea pigs (who, like humans, do not manufacture vitamin C in their bodies) more sensitive to the negative effects of histamine. J.L. Parrot and G. Richet found that significantly less histamine killed half of the guinea pigs in their experiments after 15 days on a vitamin C-deficient diet. Instead of 8 mg/kg, only 2.5 mg/kg was needed.

In his article, Dr. Clemetson reports the clinical experience of Australian doctor A. Kalokerinos. Dr. Kalokerinos was deeply disturbed by the number of deaths among the Aboriginal and Caucasian children that he vaccinated for diphtheria, whooping cough, and tetanus (DPT). He had been vaccinating them when they were brought to the clinic because of illness (such as upper respiratory infection) because he thought he might not see them again. Infection of any kind is known to cause "a sharp drop in the blood leukocyte ascorbic acid concentration," and the vitamin C levels in these children were low even before they became ill. By giving the children vitamin C, Dr. Kalokerinos was able to give them the DPT vaccine without causing more deaths.

Dr. Clemetson says that he "does not dispute the need for these inoculations...." He does, however, recommend that children with coryza and children and adults receiving multiple inoculations at the same time be given 500 mg of vitamin C in orange juice beforehand to prevent severe reactions. If possible, inoculation of debilitated infants should be postponed. In the event that convulsions occur within a day or two after vaccination, he says that vitamin C should be given by injection.

"Vaccinations, Inoculations and Ascorbic Acid" by C. Alan B. Clemetson, MD. Reprinted from The Journal of Orthomolecular Medicine, Third Quarter 1999 - Volume 14 Number 3.

COPYRIGHT 2002 The Townsend Letter Group
COPYRIGHT 2002 Gale Group

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