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Famotidine

Famotidine is a histamine H₂-receptor antagonist that inhibits stomach acid production, and is commonly used in the treatment of peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD). more...

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Clinical use

Certain preparations of famotidine are available over the counter (OTC) in various countries. In the United States, preparations of 10 mg and 20mg tablets, sometimes in combination with a more traditional antacid (brand name Pepcid Complete), are available OTC. Larger doses still require a prescription.

History and development

Famotidine was developed by Merck & Co.. The imidazole-ring of cimetidine was replaced with a 2-guanidinothiazole ring. Famotidine proved to be 30 times more active than cimetidine.

It was first marketed (as Pepcidine® and Pepcid®) in 1985. Pepcid RPD® (orally disintegrating tablets that are not swallowed) was released in 1999. Generic forms (e.g. Fluxid®, Schwarz Pharma) became available in 2001.

In the United States, a product called Pepcid Complete is available that combines famotidine with an antacid in a chewable tablet to ameliorate the relatively slow onset of effects.

Read more at Wikipedia.org

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Flurry of generic famotidine follows Pepcid patent loss - Andrx, Ivax, Myland and others launch their version - Brief Article - Statistical Data Included
From Drug Store News, 5/21/01

Andrx, Ivax, Mylan, Par Pharmaceuticals and Teva began marketing famotidine, the generic equivalent of Merck's Pepcid, just days after the drug's patent expired April 15. Pepcid sales were well over $500 million in 2000.

Pepcid is used to treat ulcers and gastroesophageal reflux disease, or GERD. Andrx and joint venture partner Carlsbad Technologies, Ivax, Mylan and Par are all marketing 20 mg and 40 mg tablets of the drug. Jerusalem-based Teva is also selling 20 mg and 40 mg famotidine in the United States and awaits FDA approval for the over-the-counter, 10mg version of the drug called Pepcid AC in the United States. Pepcid AC sales reached $120 million in the United States last year.

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