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Filgrastim

Filgrastim is a granulocyte colony-stimulating factor (G-CSF) analog used to stimulate the proliferation and differentiation of granulocytes. It is produced by recombinant DNA technology and is marketed under the trade name "Neupogen." The gene for human granulocyte colony-stimulating factor is inserted into the genetic material of Escherichia coli. The G-CSF then produced by E. coli is only slightly different from G-CSF naturally made in humans. more...

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Therapeutic uses

Filgrastim is used to treat neutropenia (a low number of neutrophils), stimulating the bone marrow to increase production of neutrophils. Causes of neutropenia include chemotherapy and bone marrow transplantation. Filgrastim is also used to increase the number of myeloid stem cells before collection by leukapheresis.

Contraindications

Filgrastim should not be used in patients with known hypersensitivity to E. coli-derived proteins.

Adverse effects

The most commonly observed adverse effect is mild-to-moderate bone pain after repeated administration and local skin reactions at the site of injection.

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Danger: Counterfeit Neupogen® . found - Filgrastim - counterfeit vials labeled as Neupogen filgrastim - for information, contact Amgen Inc - http://www.amgen.com
From AIDS Treatment News, 5/25/01

On May 10 Amgen Inc. warned medical professionals that counterfeit vials labeled as Neupogen (filgrastim) have been found in the United States (but not in other countries at that time). These vials contain a clear liquid, but no active ingredient -- a fraud that could be life-threatening to patients.

The Amgen Web site has detailed instructions for distinguishing the counterfeit product, which is easy to do, because there are differences in the lot number, packaging, and labeling. For example, lot number P000948 is counterfeit; while lot number P000890 with one expiration date is counterfeit, but the same lot number with another expiration date is probably authentic. Since other fake labels may be printed, check the Amgen Web site, http://www.amgen.com

(Try clicking Corporate Center, then Amgen News - check the May 10 or 11 press release, which has photos showing the differences, and see if there are any later press releases.)

COPYRIGHT 2001 John S. James
COPYRIGHT 2001 Gale Group

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