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Fludarabine

Fludarabine is a chemotherapy drug used in the firstline treatment of chronic lymphocytic leukemia. Because of its immunosuppression, fludarabine is also used in some conditioning regimens of non myeloablative allogeneic transplant. more...

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It is a purine analog, and is given intravenously. Fludarabine inhibits DNA synthesis by interering with ribonucleotide reductase and DNA polymerase. It is active against both dividing and resting cells.

Fludarabine is associated with profound lymphocytopenia, and as a consequence, increases the risk of opportunistic infections significantly.

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Peripheral stem cell transplantation plus monoclonal antibody therapy in treating patients with high-risk hematologic cancer, refractory breast or kidney
From Journal of Drugs in Dermatology, 11/1/04

This study is currently recruiting patients.

Sponsored by Duke Comprehensive Cancer Center National Cancer Institute (NCI)

Peripheral stem cell transplantation replaces immune cells that were destroyed by chemotherapy which was used to kill tumor cells. Sometimes the transplanted cells can make an immune response against the body's normal tissues. Treatment of the cells with a monoclonal antibody may prevent this from happening. The purpose of this phase II trial is to study the effectiveness of peripheral stem cell transplantation plus monoclonal antibody therapy in treating patients who have high-risk hematologic cancer, refractory breast or kidney cancer, or melanoma.

Study ID Numbers: CDR0000067374; DUMC-1340-99-7; NCI-G99-1617

ClinicalTrials.gov Identifier: NCT00004143

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