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Fluocinonide

Fluocinonide (a corticosteroid) constitute a class of primatily synthetic steroids used topically as an anti-inflamatory and anti-pruritic agents. more...

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<chemical> 6α,9-difluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione, cyclic 16,17-acetal with acetone,21-acetate. A topical glucocorticoid used in the treatment of eczemas.

Pharmacological action: anti-allergic agents, steroidal anti-inflammatory agents, glucocorticoids, synthetic, glucocorticoids, topical.

Chemical name: Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-6,9-difluoro-11-hydroxy-16,17-((1-methylethylidene)bis(oxy))-, (6α, 11β, 16α) -

Molecular Formula: C26H32F2O7

Mol. Wt: 494.53

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Fluocinonide 0.1% cream approved for plaque-type psoriasis
From Journal of Drugs in Dermatology, 5/1/05

Patheon Inc. announced FDA approval of Vanos[R] (fluocinonide 0.1%) cream for the treatment of plaque-type psoriasis affecting up to 10% body surface area. Vanos is a class 1 corticosteroid formulated for once or twice daily application. Approval was based on results from a double-blind, randomized clinical trial demonstrating 31% of patients achieving clearance or near-clearance of psoriatic plaques with twice daily application for 2 weeks.

The most commonly reported adverse events noted were burning sensations at application sites and headache. Hypothalamic-pituitary-adrenal axis suppression was seen in 2 of 18 patients whose mean body surface area ranged from 10% to 50%. Due to the risk of HPA axis suppression, treatment with Vanos should not exceed two weeks, nor should it exceed 60 grams per week. In addition, as its safety has not been established in this population, fluocinonide cream 0.1% should not be used in patients younger than eighteen years.

COPYRIGHT 2005 Journal of Drugs in Dermatology, Inc.
COPYRIGHT 2005 Gale Group

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