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Desipramine

Desipramine is a tricyclic antidepressant (TCA) that inhibits the reuptake of norepinephrine. It is sold under the brand names Norpramin® and Pertofrane®. It is used to treat depression, but not considered a first line treatment since the introduction of SSRI antidepressants. Desipramine is an active metabolite of imipramine. more...

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Along with other tricyclics, desipramine has found use in treating neuropathic pain. The mechanism of action seems to involve the activation, through norepinephrine reuptake inhibition, of descending pathways in the spinal cord that block pain signals from ascending to the brain. Desipramine is one of the most potent and selective medications in this respect.

Some evidence suggests that desipramine may help with ADD, and along with Wellbutrin, the only serotonergic drug that is documented for this condition.

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Desipramine: A Medical Dictionary, Bibliography, And Annotated Research Guide To Internet References $39.36 A comparison between a serotonin and a noradrenaline uptake inhibitor in endogenous depression: Clinical and biochemical findings (Bulletin / Lincoln College)
On the kinetics of antidepressants of imipramine-type Desipramine $0.87

Comorbid major depressive disorder as a prognostic factor in cocaine-abusing buprenorphine-maintained patients treated with desipramine and contingency
Depression is common among patients who abuse both opiates and cocaine, and its treatment has had mixed success. This study compares buprenorphine-maintained ...
Evidence for altered desipramine disposition in methadone-maintained patients treated for cocaine abuse
Desipramine, a drug used to treat depression, has recently been reported as useful in treating cocaine addiction. Many individuals are addicted to both ...
Use of desipramine for treatment of adult ADHD - attention deficit hyperactivity disorder - Tips from Other Journals
Evidence suggests that attention deficit hyperactivity disorder (ADHD) persists in 10 to 60 percent of young adults who had ADHD as children. A substantial ...
Two lots of desipramine recalled
Pharmaceutical Basics Inc. of Denver recalled two lots of its antidepressant desipramine in late March because of a label mix-up. People taking the finn's desipramine were advised to examine their
Psychotherapy's road to cocaine control - short-term psychotherapy more effective than desipramine in reducing cocaine use among cocaine abusers - Brief
Short-term psychotherapy that offers cocaine abusers practical strategies for maintaining abstinence sparks a marked drop in their overall cocaine use ...
Antidepressants and antiepileptic drugs for chronic non-cancer pain
The development of newer classes of antidepressants and second-generation antiepileptic drugs has created unprecedented opportunities for the treatment ...
Common problems in patients recovering from chemical dependency - Practical Therapeutics
Chemical dependency is a common, chronic disease that affects up to 25 percent of patients seen in primary care practices. The treatment goal for patients ...
Quetiapine overdose induced acute respiratory distress syndrome
INTRODUCTION: A 41 year-old male, with bipolar disorder presented after ingestion of 4500 mg of quetiapine. Within 24 hours, respiratory failure ensued, ...

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