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Detrol

Tolterodine (ATC code: G04BD) is an antimuscarinic drug that is used to treat urinary incontinence. It is sold under the trade name Detrol. more...

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Tolterodine acts on M2 and M3 subtypes of muscarinic receptors whereas most antimuscarinic treatments for overactive bladder only act on M3 receptors making them more selective. Tolterodine, however, although it acts on two types of receptors, has less side effects than other antimuscarinics eg. oxybutynin (which is selective for M3 only) as tolterodine targets the bladder more than other areas of the body. This means that less drug needs to be given daily (due to efficient targeting of the bladder) and so there are less side effects eg. hyposalivation, constipation, decreased gastric motility.

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Is tolterodine or oxybutynin the best for treatment of urge urinary incontinence? - Detrol - Ditropan - POEMs
Harvey MA, Baker K, Wells GA. Tolterodine versus oxybutynin in the treatment of urge urinary incontinence: a meta-analysis. Am J Obstet Gynecol 2001; ...
Detrol for Bladder Control: Heavily Advertised, Widely Prescribed, Minimally Useful
Center for Medical Consumers, New York, NY "Designed specifically for overactive bladder" is the message of the Detrol ads which usually feature a ...
Twice-Daily Detrol Effective for 2 Years
HILTON HEAD ISLAND, S.C. -- Tolterodine tartrate given at a dosage of 2 mg twice daily for the treatment of overactive bladder maintains its efficacy ...
Is extended-release oxybutynin or tolterodine more effective in the treatment of an overactive bladder? - Ditropan XL - Detrol
Appell RA, Sand P, Dmochowski R, et al. Prospective randomized controlled trial of extended-release oxybutynin chloride and tolterodine tartrate in the treatment of overactive bladder: results of t
ACOG guidelines on urinary incontinence in women
The American College of Obstetricians and Gynecologists (ACOG) has released recommendations on the diagnosis and treatment of urinary incontinence in ...
Selecting medications for the treatment of urinary incontinence
In response to the growing population of older patients with incontinence, pharmaceutical companies are developing new drugs to treat the condition. Before prescribing medications for incontinence,
Clinical quiz
Clinical Quiz questions are based on selected articles in this issue of American Family Physician. Answers appear in this issue. AFP has been reviewed ...
Anticholinergic approved for treatment of OAB
The U.S. Food and Drug Administration has approved a muscarinic receptor antagonist for treating overactive bladder that is more selective to the muscarinic ...

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