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Dipyridamole

Dipyridamole is a drug that inhibits platelet aggregation. more...

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  • It inhibits the enzyme adenosine deaminase which normally breaks down adenosine. This inhibition leads to increased levels of adenosine. Adenosine activates the enzyme adenylate cyclase which leads to increased cyclic AMP (cAMP) synthesis.
  • Dipyridamole also inhibits the enzyme phosphodiesterase which normally breaks down cAMP.

Both of these mechanisms lead to increased levels of cAMP within platelets. cAMP impairs platelet aggregation.

Modified release dipyridamole is used in conjunction with aspirin (Aggrenox®) in the secondary prevention of stroke and transient ischemic attack.

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Serum caffeine levels after 24-hour abstention: Clinical implications on dipyridamole (201)T1 myocardial perfusion imaging : An article from: Journal of Nuclear Medicine Technology $20.00 Drug Update: Secondary Prevention of Strokes.(Brief Article) : An article from: Family Practice News $5.95
Dipyridamole, cold pressor test, and demonstration of endothelial dysfunction: A PET study of myocardial perfusion in diabetes : An article from: The Journal of Nuclear Medicine $20.00

Use of dipyridamole in patients with recent stroke or TIA
TO THE EDITOR: Dr. Solenski's review (1) of treatment options for transient ischemic attack (TIA) discusses the additive benefits of combination therapy ...
Sensitivity, specificity, positive predictive value, and negative predictive value of the dipyridamole sestamibi stress test comparing arterial to vein
Study objectives: To determine the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of the dipyridamole ...
Dipyridamole stress echocardiography vs dipyridamole sestamibi scintigraphy for diagnosing coronary artery disease in left bundle-branch block - clinical
Study objectives: To evaluate dipyridamole stress echocardiography (DSE) for predicting coronary artery diseases (CADs) in patients with complete left ...
Aspirin And Dipyridamole For The Secondary Prevention Of Stroke
Wahlgren NG. Critical analysis of the combination of dipyridamole plus acetylsalicylic acid versus acetylsalicylic acid alone in the secondary prevention ...
Oral vs intravenous dipyridamole echocardiography for detecting coronary artery disease
The usefulness of the intravenous dipyridamole-echocardiography test (12-lead and two-dimensional [2-D] echo monitoring during dipyridamole infusion) ...
Sinus arrest associated with dipyridamole infusion
We describe a case of prolonged sinus arrest resolved by external cardiac massage following intravenous infusion of dipyridamole, during a thallium myocardial perfusion test. The arrhythmia, presu
A longitudinal evaluation of dipyridamole drug use in an ambulatory elderly population
Study objective: To determine the pattern of dipyridamole use over the past 14 years. Design: A longitudinal health screening program of ambulatory elderly ...
Severe bronchospasm followed by respiratory arrest during thallium-dipyridamole imaging
Jean Lette M.D., F.C.C.P.; Michel Cerino M.D.; Michel Laverdiere M.D.; Jacques Tremblay M.D.; and Julie Prenovault M.D. We describe the occurrence ...

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