Find information on thousands of medical conditions and prescription drugs.

Donepezil

Donepezil, marketed under the trade name AriceptĀ® (Eisai), is a centrally acting reversible acetyl cholinesterase inhibitor. Its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine. It is well absorbed in the gut with an oral bioavailability of 100% and easily crosses the blood-brain barrier. Because it has a half life of about 70 hours, it can be taken once a day. Initial dose is 5 mg per day, which can be increased to 10 mg per day after an adjustment period of at least 4 weeks. more...

Home
Diseases
Medicines
A
B
C
D
Dacarbazine
Dactinomycin
Dalmane
Danazol
Dantrolene
Dapoxetine
Dapsone
Daptomycin
Daraprim
Darvocet
Darvon
Daunorubicin
Daunorubicin
Daypro
DDAVP
Deca-Durabolin
Deferoxamine
Delsym
Demeclocycline
Demeclocycline
Demerol
Demulen
Denatonium
Depakene
Depakote
Depo-Provera
Desferal
Desflurane
Desipramine
Desmopressin
Desogen
Desogestrel
Desonide
Desoxyn
Desyrel
Detrol
Dexacort
Dexamethasone
Dexamfetamine
Dexedrine
Dexpanthenol
Dextran
Dextromethorphan
Dextromoramide
Dextropropoxyphene
Dextrorphan
Diabeta
Diacerein
Diacetolol
Dial
Diamox
Diazepam
Diazoxide
Dibenzepin
Diclofenac
Diclohexal
Didanosine
Dieldrin
Diethylcarbamazine
Diethylstilbestrol
Diethyltoluamide
Differin
Diflucan
Diflunisal
Digitoxin
Digoxin
Dihydrocodeine
Dihydroergotamine
Dihydrotachysterol
Dilantin
Dilaudid
Diltahexal
Diltiazem
Dimenhydrinate
Dimercaprol
Dimetapp
Dimethyl sulfoxide
Dimethyltryptamine
Dimetridazole
Diminazene
Diovan
Dioxybenzone
Diphenhydramine
Diphenoxylate
Dipipanone
Dipivefrine
Diprivan
Diprolene
Diproteverine
Dipyridamole
Disulfiram
Disulfiram
Dizocilpine
Dobutamine
Docetaxel
Docusate sodium
Dofetilide
Dolasetron
Dolobid
Dolophine
Domperidone
Donepezil
Dopamine
Dopram
Doral
Doramectin
Doriden
Dornase alfa
Doryx
Dostinex
Doxapram
Doxazosin
Doxepin
Doxil
Doxil
Doxorubicin
Doxy
Doxycycline
Doxyhexal
Doxylamine
Drisdol
Drixoral
Dronabinol
Droperidol
Drospirenone
Duloxetine
Durabolin
Duragesic
Duraphyl
Duraquin
Dutasteride
Dv
Dyclonine
E
F
G
H
I
J
K
L
M
N
O
P
Q
R
S
T
U
V
W
X
Y
Z

The clinical utility of donepezil is controversial. Presently, there is no proof that use of donepezil or other similar agents alters the course or progression of Alzheimer's disease. However, controlled studies have shown modest benefits in cognition and behavior with this and similar agents. Therefore, many neurologists, psychiatrists, and primary care physicians use donepezil in patients with Alzheimer's disease. As of the 22 March 2005, the UK National Institute for Clinical Excellence (NICE) withdrew its recommendation for use of the drug for mild-to-moderate AD, on the basis that there is no significant improvement in functional outcome; of quality of life or of behavioral symptoms. However, these data conflict with those of other reports, as is often the case in medicine.

Donepezil is sometimes used in combination with Memantine, a new agent for Alzheimer's disease which is in the same chemical class. The response to both together is superior to either alone.

Donepezil has been tested in other disorders which cause dementia including Lewy body dementia and Vascular dementia, but it is not currently approved for these indications.

Sources

  • Brenner, G. M. (2000). Pharmacology. Philadelphia, PA: W.B. Saunders Company. ISBN 0-7216-7757-6
  • Canadian Pharmacists Association (2000). Compendium of Pharmaceuticals and Specialties (25th ed.). Toronto, ON: Webcom. ISBN 0-919115-76-4

Read more at Wikipedia.org


[List your site here Free!]


Donepezil: A Medical Dictionary, Bibliography, And Annotated Research Guide To Internet References $39.36 Donepezil boosts AD patients' behavior over time.(Geriatrics) : An article from: Internal Medicine News $5.95
Don't Interrupt Donepezil Use in Alzheimer's. : An article from: Family Practice News $5.95

Donepezil in the treatment of vascular dementia
Clinical Question Is donepezil effective in the treatment of vascular dementia? Evidence-Based Answer Donepezil in a dosage of 10 mg daily provides ...
Donepezil shows short-term benefit in slowing MCI progression to AD; vitamin E use has little advantage
Donepezil therapy, compared to placebo, may reduce the rate of progression to Alzheimer's disease (AD) in patients with mild cognitive impairment (MCI), ...
Donepezil may improve mild cognitive impairment
People with mild cognitive impairment taking the medication donepezil were at reduced risk of progressing to Alzheimer's disease during the first 18 ...
Donepezil delays nursing home placement - Tips from Other Journals
Factors that predict nursing home placement in patients with Alzheimer's disease include worsening dementia, behavior disturbances, and caregiver burden.
Donepezil minimally effective for patients with vascular dementia
Black S, Roman GC, Geldmacher DS, et al; Donepezil 307 Vascular Dementia Study Group. Efficacy and tolerability of donepezil in vascular dementia: positive ...
An N-of-1 randomized controlled trial of donepezil in the treatment of non-progressive amnestic syndrome - `N-of-1 trial' - Abstract
Introduction: a professional man sustained a residual, persisting, isolated impairment of short-term memory secondary to severe carbon monoxide poisoning.
Donepezil May Boost Memory In Epilepsy - Brief Article
LOS ANGELES -- Donepezil may improve memory in patients with epilepsy Jennifer Bortz, Ph.D., reported in a poster session at the annual meeting of the ...
Donepezil Allows Basic and Complex Daily Activities - Brief Article
DALLAS -- Donepezil preserves the ability to perform both basic and complex activities of daily living in patients with Alzheimer's disease, Dr. John ...

Home Contact Resources Exchange Links ebay