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Methylcellulose

Methylcellulose (or methyl cellulose) is a chemical compound derived from cellulose. It is a hydrophilic white powder in pure form and dissolves in cold (but not in hot) water, forming a clear viscous solution or gel. It is sold under a variety of trade names and is used as a thickener and emulsifier in various food and cosmetic products, and also as a treatment of constipation. Like cellulose, it is not digestible, not toxic, and not allergenic. more...

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Chemistry

Chemically, methylcellulose is a methyl ether of cellulose, arising from substituting the hydrogen atoms of some of cellulose's hydroxyl groups -OH with methyl groups -CH3, forming -OCH3 groups.

Different kinds of methylcellulose can be prepared depending on the number of hydroxyl groups so substituted. Cellulose is a polymer consisting of numerous linked glucose molecules, each of which exposes three hydroxyl groups. The Degree of Substitution (DS) of a given form of methylcellulose is defined as the average number of substituted hydroxyl groups per glucose. The theoretical maximum is thus a DS of 3.0, however more typical values are 1.3 - 2.6.

Different methylcellulose preparations can also differ in the average length of their polymer backbones.

Methylcellulose does not occur naturally and is synthetically produced by heating cellulose with caustic solution (e.g. a solution of sodium hydroxide) and treating it with methyl chloride.

The CAS number of methylcellulose is 9004-67-5.

Solubility and temperature

Methylcellulose dissolves in cold water. Higher DS-values result in lower solubility, because the polar hydroxyl groups are masked. The chemical is not soluble in hot water, which has the paradoxical effect that heating a saturated solution of methylcellulose will turn it solid, because methylcellulose will precipitate out. The temperature at which this occurs depends on DS-value, with higher DS-values giving lower precipitation temperatures.

Preparing a solution of methylcellulose with cold water is difficult however: as the powder comes into contact with water, a gluey layer forms around it, and the inside remains dry. A better way is to first mix the powder with hot water, so that the methylcellulose particles are well dispersed in the water, and cool down this dispersion while stirring, leading to the dissolution of those particles.

Uses

Thickener and emulsifier

Methylcellulose is often added to hair shampoos, tooth pastes and liquid soaps, to generate their characteristic thick consistency. This is also done for foods, for example ice cream or whipped cream. Methylcellulose is also an important emulsifier, preventing the separation of two mixed liquids.

The E number of methylcellulose as food additive is E461.

Treatment of constipation

When eaten, methylcellulose is not absorbed by the intestines but passes through the digestive tract undisturbed. It attracts large amounts of water into the colon, producing a softer and bulkier stool. It is used to treat constipation, diverticulosis, hemorrhoids and irritable bowel syndrome. It should be taken with sufficient amounts of fluid to prevent dehydration.

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Guideline for chronic constipation management
From Journal of Family Practice, 11/1/05

American College of Gastroenterology Chronic Constipation Task Force. An evidence-based approach to the management of chronic constipation in North America. Am J Gastroenterol 2005; 100:S1-S4.

* Clinical Question

What is the best approach to evaluating and treating chronic constipation?

Study Design Systematic review

Setting Outpatient (any)

Synopsis

This evidence-based guideline is based on a careful accompanying systematic review. Chronic constipation is defined as infrequent or difficult stool passage, incomplete evacuation, prolonged time to stool, or the need for manual maneuvers to pass stool, for at least 3 months. It is estimated that the prevalence of chronic constipation is approximately 15%; it is more common in women.

Patients with alarm symptoms for cancer or bleeding should undergo a thorough diagnostic work-up. Otherwise, routine diagnostic testing is not recommended for patients with chronic constipation who have no alarm symptoms and no signs of organic disorder (such as hypothyroidism) after a careful history and physical examination.

Regarding treatment: of the bulking agents, psyllium increases stool frequency but data are insufficient regarding calcium polycarbophil, methylcellulose, or bran. There is insufficient evidence regarding the efficacy of stool softeners or milk of magnesia. There is good evidence that polyethylene glycol and lactulose both improve stool frequency and consistency.

There are few data regarding stimulant laxatives, but the available data suggest that they are of little benefit. Tegaserod (Zelnorm) improves the frequency and consistency of stools and reduces straining, particular in younger patients. There are insufficient data regarding alternative treatments, herbal supplements, lubricants, or combination laxatives.

* Bottom Line

Diagnostic testing is not needed for most patients with chronic constipation. The evidence is strongest for the efficacy of psyllium, polyethylene glycol, lactulose, and tegaserod. Research is not available to support the routine use of stimulant laxatives, lubricants, stool softeners, calcium polycarbophil, bran, or any herbal products. (LOE=1a)

FAST TRACK Routine diagnostic testing is not recommended for patients without alarm symptoms or signs of organic disorder

COPYRIGHT 2005 Dowden Health Media, Inc.
COPYRIGHT 2005 Gale Group

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