Metoprolol chemical structure

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Metoprolol

Metoprolol is a selective beta₁ receptor blocker used in treatment of several diseases of the cardiovascular system. It is marketed under the brand name Lopressor® by Novartis, and Toprol® (in the USA), Seleken® or Selokeen® (elsewhere) by AstraZeneca and as Corvitol® by Berlin-Chemie AG. more...

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Metamizole sodium

Methamphetamine

Methylcellulose

Methylergometrine

Methylphenidate

Methylphenobarbital

Methylprednisolone

Methyltestosterone

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It should be noted that Lopressor® refers to metoprolol tartrate, while Toprol® refers to metoprolol succinate.

Properties:

Cardioselective
Lipophilic
Without intrinsic sympathomimetic activity (ISA)
Without membrane stabilizing activity
Short half-life must be taken at least twice daily or SR preparations

Indications:

Essential hypertension
Arrhythmias
Coronary heart disease (prevention of angina attacks)
Secondary prevention after a myocardial infarction
Low dosed treatment of some forms of heart failure (see MERIT-HF study¹)
Migraine prophylaxis
Adjunct in treatment of hyperthyroidism

In the United States and most other countries, this medication is available only by prescription.

Read more at Wikipedia.org

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		Pharmacometric issues in modeling and simulation: Metoprolol population pharmacokinetics and pharmacodynamics in healthy subjects : (Dissertation) $55.00			Migraine drugs.(Drugs, Pregnancy, And Lactation) : An article from: Family Practice News $5.95

		Latest COMET trial data stir continued debate on comparison: Metoprolol vs. Carvedilol.(Clinical Rounds) : An article from: Family Practice News $5.95


	What is the correct dose of Metoprolol in heart failure? - Tips from Other Journals - Brief Article The use of beta-adrenergic blocking agents in the treatment of heart failure and left ventricular dysfunction has provided a significant improvement ... From American Family Physician, 1/15/03 by Karl E. Miller

	Metoprolol Is a Safe Treatment in Patients with Severe CHF - congestive heart failure Beta-adrenergic receptor blockers have been shown to reduce morbidity and mortality in patients with mild to moderate congestive heart failure (CHF). From American Family Physician, 3/15/02 by Karl E. Miller

	Metoprolol CR/XL in Patients with Chronic Heart Failure - Brief Article Angiotensin-converting enzyme (ACE) inhibitors are considered standard therapy in patients with left ventricular systolic dysfunction as the cause of ... From American Family Physician, 9/1/00 by Grace Brooke Huffman

	AstraZeneca last month charged the generic company Andrx for an alleged impending patent infringement of AstraZeneca's Toprol-XL 50 mg - metoprolol succinate AstraZeneca last month charged the generic company Andrx for an alleged impending patent infringement of AstraZeneca's Toprol-XL (metoprolol succinate) ... From Drug Store News, 3/1/04 by James Frederick

	Carvedilol or Metoprolol for chronic heart failure? - Tips from Other Journals Chronic heart failure is a common and disabling condition for which current treatment guidelines recommend combination therapy with diuretics, angiotensin-converting ... From American Family Physician, 2/15/04 by Anne D. Walling

	Left ventricular dysfunction: Carvedilol vs. Metoprolol - Tips from Other Journals Early studies with selective beta blockers, such as bisoprolol and metoprolol XL, and with nonselective beta blockers, such as carvedilol, have demonstrated ... From American Family Physician, 2/15/04 by Richard Sadovsky

	Does Metoprolol Improve Survival in CHF? The prevalence of chronic heart failure (CHF) is increasing as the proportion of elderly persons in the population increases. Mortality associated with ... From American Family Physician, 11/1/99 by Anne D. Walling

	Immediate- vs extended-release metoprolol in heart failure - Letters to the Editor TO THE EDITOR: The Clinical Inquiries article by Jon Neher and Sarah Safranek ("What is the most effective beta-blocker for heart failure?," J Fam ... From Journal of Family Practice, 8/1/03 by Ben Huneycutt

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