Find information on thousands of medical conditions and prescription drugs.
Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) widely marketed under various trademarks including Act-3, Advil, Brufen, Motrin, Nuprin, and Nurofen; a standing joke about some athletes' regular use has produced "Vitamin I" as a slang term for it. It is used for relief of symptoms of arthritis, primary dysmenorrhoea, and fever; and as an analgesic, especially where there is an inflammatory component. Ibuprofen was developed by the research arm of Boots Group. more...
Low doses of ibuprofen (200 mg, and sometimes 400 mg) are available over the counter (OTC) in most countries. Ibuprofen has a dose-dependent duration of action of approximately 4–8 hours, which is longer than suggested by its short half-life. The recommended dose varies with body mass and indication. Generally, the oral dose is 200–400 mg (5–10 mg/kg in children) every 4–6 hours, up to a usual maximum daily dose of 800–1200 mg. Under medical direction, a maximum daily dose of 3200 mg may sometimes be used.
Approved clinical indications for ibuprofen include:
- Rheumatoid arthritis (DMARDs should also be considered)
- Osteoarthritis, ibuprofen can reduce pain and, if present, joint inflammation
- Juvenile rheumatoid arthritis, alone or with corticosteroids
- Morbus Bechterew (spondylitis ankylosans) together with corticosteroids
- Rheumatic fever, together with antibiotic therapy
- Acute gout attack, ibuprofen is not useful for chronic treatment
- Primary dysmenorrhoea (ibuprofen proved superior to placebo and propoxyphen, and at least as effective as aspirin)
- Pericarditis, chiefly after myocardial infarction, to reduce pain, fever and inflammation
- Minor aches and pains such as toothache, backache, fever and pain associated with common flu, symptomatic relief of influenza, shingles, and postoperative pain
- Sporting injuries and pain after mild to moderate trauma
- Headache including mild to moderate migraine attack
Off-Label and investigational use
- As with other NSAIDs, ibuprofen may be useful in the treatment of severe orthostatic hypotension (PMID 7041104)
- In some studies, ibuprofen showed superior results compared to placebo in the prophylaxis of Alzheimer's disease, when given in low doses over a long time (PMID 16195368). Further studies are needed to confirm the results, before ibuprofen can be recommended for this indication.
- Ibuprofen has been associated with a lower risk of Parkinson's disease, and may delay or prevent Parkinson's disease. Aspirin, other NSAIDs, and acetaminophen had no effect on the risk for Parkinson's (PMID 16240369). Further research is warranted before recommending ibuprofen for this use.
In Europe and Australia, ibuprofen lysine (ibuprofenlysinat, the lysine salt of ibuprofen) is licensed for treatment of the same conditions as ibuprofen. Ibuprofen lysine is said to have a more rapid onset of action compared to base ibuprofen.
Mechanism of action
Ibuprofen is an NSAID which is believed to work through inhibition of cyclooxygenase (COX); thus inhibiting prostaglandin synthesis. As with other NSAIDs, ibuprofen inhibits platelet aggregation, but is not used therapeutically for this action since it is a minor and reversible effect.
Read more at Wikipedia.org
• [List your site here Free!]
Over-the-counter drugs such as aspirin, Motrin, Advil, and Aleve may cause shoulder injuries to heal more slowly|
+ Popping an aspirin for occasional shoulder pain is fine, but according to a study from the American Orthopaedic Society for Sports Medicine, over-the-counter ...
From Men's Fitness,
Children's Motrin Grape Chewables Alert|
McNeil Consumer and Specialty Pharmaceuticals alerted customers nationwide that one lot of Children's Motrin (ibuprofen) Grape ChewableTablets may mistakenly ...
From Nurse Practitioner,
Consumer alert on Children's Motrin|
McNeil Consumer & Specialty Pharmaceuticals has issued an alert that one manufacturing lot of Children's Motrin (ibuprofen) Grape Chewable Tablets ...
From FDA Consumer,
Tests your doctor may not mention|
newborn There are at least 28 genetic disorders, such as sickle-cell anemia, for which newborns can be tested. Yet according to the March of Dimes, ...
by Kyissa Jemine
Dangerous duos: mindlessly popping pillseven the seemingly harmless, over-the-counter varietycan be a critical mistake, especially if you were|
THIS + THIS = THIS Tetracycline Milk, cheese, or Reduces the drug's (an acne medication) calcium ...
From Men's Fitness,
by Elizabeth Ward
Women building a future: when people work together, great things can happen. Three dedicated volunteers with Habitat for Humanity talk about the rewards|
What drives a woman to pick up a hammer and demolish the second floor of a house? For Katrina Sullivan, the catalyst was Habitat for Humanity, as it ...
From Better Homes & Gardens,
Are you making the healthiest choices?|
Every day, you make choices about your health and well--being. But are you making the right ones? Take another look at some of the decisions you face ...
Simple relief: kick pain to the curb|
When the Motrin's M.I.A. and the gym or job have left you aching, try one of these alternate pain-busters. * Oil your joints. A Temple University study found that the combo of ibuprofen and gluco
From Men's Fitness,