Metoprolol chemical structure
Find information on thousands of medical conditions and prescription drugs.

Metoprolol

Metoprolol is a selective beta1 receptor blocker used in treatment of several diseases of the cardiovascular system. It is marketed under the brand name Lopressor® by Novartis, and Toprol® (in the USA), Seleken® or Selokeen® (elsewhere) by AstraZeneca and as Corvitol® by Berlin-Chemie AG. more...

Home
Diseases
Medicines
A
B
C
D
E
F
G
H
I
J
K
L
M
Macrodantin
Maprotiline
Marcaine
Marezine
Marijuana
Marinol
Marplan
Matulane
Maxair
Maxalt
Maxolon
MDMA
Measurin
Mebendazole
Mebendazole
Meclofenoxate
Medrol
Mefenamic acid
Mefloquine
Melagatran
Melarsoprol
Meloxicam
Melphalan
Memantine
Metadate
Metamfetamine
Metamizole sodium
Metandienone
Metaxalone
Metenolone
Metformin
Methadone
Methamphetamine
Methaqualone
Metharbital
Methcathinone
Methenamine
Methionine
Methocarbamol
Methohexital
Methotrexate
Methotrexate
Methoxsalen
Methylcellulose
Methyldopa
Methylergometrine
Methylin
Methylphenidate
Methylphenobarbital
Methylprednisolone
Methyltestosterone
Methysergide
Metiamide
Metoclopramide
Metohexal
Metoprolol
Metrogel
Metronidazole
Metyrapone
Mobic
Moclobemide
Modafinil
Modicon
Monopril
Montelukast
Motrin
Moxidectin
Moxifloxacin
Moxonidine
MS Contin
Mucinex
Mucomyst
Mupirocin
Mupirocin
Muse
Mycitracin
Mycostatin
Myfortic
Mykacet
Mykinac
Myleran
Mylotarg
Mysoline
Phentermine
N
O
P
Q
R
S
T
U
V
W
X
Y
Z

It should be noted that Lopressor® refers to metoprolol tartrate, while Toprol® refers to metoprolol succinate.

Properties:

  • Cardioselective
  • Lipophilic
  • Without intrinsic sympathomimetic activity (ISA)
  • Without membrane stabilizing activity
  • Short half-life must be taken at least twice daily or SR preparations

Indications:

  • Essential hypertension
  • Arrhythmias
  • Coronary heart disease (prevention of angina attacks)
  • Secondary prevention after a myocardial infarction
  • Low dosed treatment of some forms of heart failure (see MERIT-HF study1)
  • Migraine prophylaxis
  • Adjunct in treatment of hyperthyroidism

In the United States and most other countries, this medication is available only by prescription.

Read more at Wikipedia.org


[List your site here Free!]


What is the correct dose of Metoprolol in heart failure? - Tips from Other Journals - Brief Article
From American Family Physician, 1/15/03 by Karl E. Miller

The use of beta-adrenergic blocking agents in the treatment of heart failure and left ventricular dysfunction has provided a significant improvement in survival and reduced the need for hospitalization for worsening heart failure. Multiple studies have shown that the use of various beta-adrenergic blocking agents may provide a reduction of approximately 35 percent in mortality. All of these studies have initiated treatment with a low-dose beta blocker, with titration to the maximum dose or to the highest dose tolerated. Some patients are unable to tolerate maximum doses of beta-adrenergic blockers, and they may not reach the goal of maximum dose. This factor raises the question of whether patients who cannot tolerate the maximum dose need to reach this goal to have the best outcome during beta-adrenergic blockade therapy. Wikstrand and colleagues studied the effect of low-dose beta-adrenergic blockade therapy on outcomes in patients with heart failure.

The study population was a subgroup of the Metoprolol Controlled-Release/Extended-Release (CR/XL) Randomized Intervention Trial in Chronic Heart Failure (MERIT-HF) study. Patients in the study had symptomatic heart failure in New York Heart Association (NYHA) Class II to IV, ejection fraction of 40 percent or less, and were taking optimal diuretic therapy and an angiotensin-converting enzyme inhibitor. After a two-week placebo phase, participants were randomly assigned to start metoprolol CR/XL at 12.5 mg or 25 mg per day, or placebo. Patients in the metoprolol-treated group had their dose doubled every two weeks to a maximum of 200 mg once daily or the highest tolerated dose. Primary outcome measures included total mortality, all-cause hospitalizations, sudden death, death from worsening heart failure, cardiac deaths, hospitalizations from worsening heart failure, and nonfatal acute myocardial infarctions. The study group was divided into two subgroups of patients who were able to titrate their metoprolol to more than 100 mg per day (i.e., high dose) and patients who were unable to tolerate the maximum dose and were taking 100 mg or less per day (i.e., low dose).

The low-dose group actually had a somewhat higher risk compared with the high-dose group. Heart rate reduction was the same in the two groups, indicating a higher sensitivity to beta-adrenergic blocking agents in the low-dose group. Reduction of total mortality and all other outcome measures was similar in the low- and high-dose groups (see accompanying table).

The authors conclude that risk reduction was similar between the low- and high-dose metoprolol groups in the treatment of heart failure. They note that this may be a result of patients' sensitivity to beta-adrenergic blocking. They add that an individualized dose-titration regimen for metoprolol can be guided by patients' ability to tolerate the medication and their heart rate response.

COPYRIGHT 2003 American Academy of Family Physicians
COPYRIGHT 2003 Gale Group

Return to Metoprolol
Home Contact Resources Exchange Links ebay