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Accutane

Isotretinoin is a generic medication used for the treatment of severe acne and most commonly known under the brands Accutane and Roaccutane. It is a retinoid, meaning it is derived from vitamin A and is found naturally in the body, produced by the liver in small quantities. more...

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History

Prior to the development of isotretinoin, the mainstay treatment of severe acne was oral antibiotics such as the tetracyclines and erythromycin. While these drugs have proven efficacy, they worked against only one contributing factor of acne, Propionibacterium acnes bacteria. The antibiotics gradually became less effective over time as more resistant strains of the bacterium became prominent.

An early, effective treatment of acne was high doses of the fat soluble vitamin A. At these dose levels (sometimes 500,000 IU per day) effects such as reduced production of sebum and dry hair could be noticed. However the vitamin also had many other prominent side effects which inhibited its widespread use.

The development of the derivative of retinoic acid, isotretinoin (13-cis-retinoic acid), and its release in 1982 by Hoffmann-La Roche was a great step forward in the treatment of acne. The synthetic compound provided better therapeutic benefit than vitamin A, while also producing fewer side effects. In February 2002 Roche's patents for isotretinoin expired, there are now many other companies selling cheaper generic versions of the drug.

Today isotretinoin is usually prescribed after other acne treatments have failed to produce results. The treatment of acne usually begins with topicals, moves onto oral antibiotics (or a combination) and finally isotretinoin therapy. This is because other treatments, while less effective than isotretinoin, produce far fewer side effects.

Brand names

Isotretinoin is produced under many brand names by many manufacturers. It is available typically as 5 mg, 10 mg, 20 mg and (in the USA) 40 mg capsules.

Some brands of isotretinoin include:

  • Accure® by Alphapharm
  • Accutane® and Roaccutane® by Roche
  • Aknenormin® by Hermal
  • Amnesteem® by Mylan
  • Ciscutan® by Pelpharma
  • Claravis® by Barr
  • Isohexal® by Hexal Australia
  • Isotroin® by Cipla
  • Oratane® by Douglas Pharmaceuticals
  • Sotret® by Ranbaxy

Indications

Isotretinoin is indicated for treatment for a number of dermatological conditions, most commonly acne. It is generally not used as a first-line treatment due to the potential side effects. Antibiotics (such as the tetracyclines) are usually prescribed before isotretinoin.

Severe forms of acne (conglobata, fulminans and nodulocystic) as well as acne that scars can be successfully treated with isotretinoin.

Acne that has not responded to other treatment will usually respond to isotretinoin. Dysmorphophobic patients may also be prescribed isotretinoin.

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Dermatologists Would Register to Prescribe Accutane. : An article from: Skin & Allergy News $5.95 Voluntary Accutane teratogenicity management plan called inadequate: Pediatrician critical of SMART. (Rx).(Brief Article) : An article from: Family Practice News $5.95
Medication Guide Will Inform Accutane Users.(Brief Article) : An article from: Family Practice News $5.95

A warning about Accutane
I was disappointed that "Strategies for Clear Skin" (Beauty in Action, March) neglected to mention that one of the most serious side effects ...
FDA plans for increased monitoring of Accutane
The U.S. Food and Drug Administration is strengthening required monitoring of isotretinoin (Accutane[R]) in further efforts to reduce the risks of fetal ...
Generic Accutane faces potential delays - Pharmacy Watch - Hoffman-LaRoche files citizen's petition - Brief Article
Generic Accutane faces potential delays. (Pharmacy Watch).(Hoffman-LaRoche files citizen's petition)
Yellow means go for Accutane scripts - Brand Watch - Pregnancy Prevention Program for Women on Accutane, Hoffman-La-Roche - Brief Article
Yellow means go for Accutane scripts. (Brand Watch).(Pregnancy Prevention Program for Women on Accutane, Hoffman-La-Roche)
Companies warned about unapproved accutane - Updates
The FDA has sent letters to several firms warning them to stop illegally selling an unapproved, mislabeled version of the acne drug Accutane (isotretinoin).
Accutane prescription update - Extra Bodyfit - Brief Article
Used to treat the most serious form of acne, Accutane can have dangerous side effects for pregnant women, including fetal death. Health authorities have ...
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Accutane Teratogenicity Program called inadequate - Voluntary Provisions seen as Problematic
MAUI, HAWAII -- SMART, the new teratogenicity management program for Accutane, does not go far enough because too many of the provisions are voluntary, ...

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