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Amikacin

Amikacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Amikacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. more...

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Amikacin may be administered once or twice a day but must be given by the intravenous or intramuscular route. There is no oral form available. Dosage must be adjusted in people with kidney failure.

Amikacin is most often used for treating severe, hospital-acquired infections with multidrug resistant Gram negative bacteria such as Pseudomonas aeruginosa, Acinetobacter, and Enterobacter. Amikacin may be combined with a beta-lactam antibiotic for empiric therapy for people with neutropenia and fever.

Side effects of amikacin are similar to other aminoglycosides. Kidney damage and hearing loss are the most important effects. Because of this potential, blood levels of the drug and markers of kidney function (creatinine) may be monitored.

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The Amikin (amikacin sulfate) gallery of medical history (Structural engineering and engineering materials)

Susceptibility of Mycobacterium ulcerans to a combination of amikacin/rifampicin
Marsollier, L., Prevot, G., Honore, N., Legras, P., Manceau, A. L., Payan, C., Kouakou, H., and Carbonnelle, B. Susceptibility of Mycobacterium ulcerans ...
Stability of amikacin sulfate in AutoDose Infusion System bags
Abstract The objective of this study was to evaluate the physical and chemical stability of amikacin 25 mg/100 mL and 500 mg/100 mL as the sulfate salt ...
Salmonella and Campylobacter spp. in northern elephant seals, California
Campylobacter and Salmonella spp. prevalence and antimicrobial drug sensitivity were determined in northern elephant seals that had not entered the water and seals that were stranded on the Califor
Resistance due to aminoglycoside modifying enzymes in Pseudomonas aeruginosa isolates from burns patients
Background & objective: Enzymatic modifications of aminoglycosides result in high-level resistance in numerous bacterial species. However, the data on ...
Re-emergence of multi-drug resistant Shigella dysenteriae with added resistance to ciprofloxacin in north India & their plasmid profiles
Background & objectives: Multi drug resistant Shigellae pose a major threat in control of shigellosis with. Shigella dysenteriae being the most prevalent ...
Death: a one-compartment drug model equation
PURPOSE: To find an easier way to estimate and use serum levels of vancomycin and aminoglycosides. METHODS: The one compartment model with volume of distribution (Vd) in liters, and drug clearanc
Impact of clinical guidelines in the management of severe hospital-acquired pneumonia
Study objectives: To asses the impact of locally developed antimicrobial treatment guidelines in the initial empiric treatment of ICU patients with severe hospital-acquired pneumonia (HAP). Desig
Nosocomial pneumonia and antibiotic resistance
PURPOSE: The emergence of antibiotic resistant pathogens poses a significant threat to patients with nosocomial pneumonia. It is therefore important ...

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