Tissue plasminogen activator (PLAT) is a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. PLAT is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein.This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. more...
Alternative splicing of the PLAT gene, PLAT, produces three transcripts.
Recombinant PLAT is used in diseases which feature blood clots, such as myocardial infarction and stroke. To be effective, PLAT must be administered within the first six or so hours of the attack. Because of this, only about 3% of patients qualify for this treatment. Since PLAT dissolves blood clots, there is risk of hemorrhage with its use.
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