Doxorubicin chemical structure
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Adriamycin

Doxorubicin or adriamycin is a DNA-interacting drug widely used in chemotherapy. It is an anthracycline and structurely closely related to daunomycin, and also intercalates DNA. It is commonly used in the treatment of uterine cancer and ovarian cancer, as well as some other cancers. more...

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Doxil® is a liposome-encapsulated dosage form of doxorubicin made by Johnson & Johnson. Its main benefits are a reduction in cardiotoxicity. It follows the similar preparation of daunorubicin in a liposomal carrier.

Mechanism of Action

Doxorubicin acts by binding to DNA where it can inhibit the progression of the enzyme topoisomerase II, which unwinds DNA for transcription. Doxorubicin stabilises the topoisomerase II complex after it has broken the DNA chain for replication, preventing the DNA double helix from being resealed and thereby stopping the process of replication.

Side Effects

Acute side-effects of doxorubicin are nausea, vomiting, decrease in white blood cells and hair loss. When the cumulative dose of doxorubicin reaches 450mg/m2, the risk of congestive heart failure dramatically increases.

Clinical Use

Doxorubicin is a commonly used to treat Hodgkins disease, breast cancer, lung cancer, soft tissue sarcoma, Kahlers disease.

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THE INDUCTION OF GC TO AT TRANSITION MUTATIONS WITH ADRIAMYCIN IN THE BACTERIUM SALMONELLA TYPHIMURIUM. : An article from: The Texas Journal of Science $5.95 International Symposium on Adriamycin $86.66
Exacerbation of adriamycin-induced cardiac injury in inducible nitric oxide synthase null mice is alleviated by overexpression of manganese superoxide dismutase : (Dissertation) $55.00

Antioxidants reduce side effects in ovarian CA patients on adriamycin/cytoxin
Sieja K, Talerczyk M. Selenium as an element in the treatment of ovarian cancer in women receiving chemotherapy. Gynecol Oncol 2004;93:320-7. [ILLUSTRATION ...
Inositol hexaphosphate enhances the anti-proliferative effects of adriamycin and tamoxifen in breast cancer - IP6 - Brief Article
The current treatment of breast carcinomas recognizes the importance of combination therapy in order to increase efficacy and decrease side effects of ...
Antioxidant nutrients and adriamycin toxicity
Quiles J, Huertas J, Battino M, et al. Toxicology 2002; 180:79. The anthracycline antibiotic adriamycin (doxorubicin) is one of the most effective ...
Interactions of adriamycin, cytochrome c, and serum albumin with lipid monolayers containing poly(ethylene glycol)-ceramide
ABSTRACT Poly(ethylene glycol)^sub 2000^C^sub 20^ceramide (PEG-Cer) containing monolayers at an air/water interface were characterized by measuring their ...
Binding of adriamycin to liposomes as a probe for membrane lateral organization
ABSTRACT A stopped-flow spectrofluorometer equipped with a rapid scanning emission monochromator was utilized to monitor the binding of adriamycin to phospholipid liposomes. The latter process is evi
Adjuvant chemotherapy benefits all breast cancer patients
Breast cancer incidence increases with age. The use of systemic adjuvant chemotherapy to treat early-stage breast cancer has been shown to improve overall ...
A unique case of exophthalmos in a patient with recurrent pleural effusions
INTRODUCTION: Erdheim-Chester disease is a rare histiocytosis, which must be considered in patients with diffuse xanthogranulomatous infiltrations. The diagnosis of ECD requires a vigilant physicia
Influence of DL ?-lipoic acid and vitamin-E against doxorubicin-induced biochemical and histological changes in the cardiac tissue of rats
Byline: S. Ayaz, U. Bhandari, K. Pillai Objective: The present study was undertaken to find out the preventive and curative role of lipoic acid (LA) ...

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