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Astemizole

Astemizole is a second generation antihistamine that has a long duration of action.

However, it has been withdrawn from the marketplace in most countries because of rare but potentially fatal interactions with strong CYP34A enzyme inhibitors.

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Astemizole in Asthma $28.90 Astemizole: A new, non-sedative, long-acting Hb1s-antagonist : proceedings of a symposium held in Beerse, Belgium, October, 1983 (The Medicine Publishing Foundation symposium series)

Astemizole Withdrawn from the Market
The antihistamine astemizole (Hismanal) has been voluntarily withdrawn from the market by the manufacturer. Since the approval of the drug by the U.S.
Single-dose effect of astemizole on bronchoconstriction induced by histamine in asthmatic subjects
Chantale Benoit; Jean-Luc Malo, M.D.; Heberto Ghezzo, Ph.D.; and Andre Cartier, M.D. Study Objective: Astemizole, administered for seven days to asthmatic subjects, had an effect of bronchoconst
Cardiac effects of astemizole overdose in children - Tips from Other Journals
Astemizole is a nonsedating, long-acting antihistamine widely used in the treatment of allergic rhinitis, allergic conjunctivitis, urticaria and chronic ...
Five-day telithromycin once daily is as effective as 10-day clarithromycin twice daily for the treatment of acute exacerbations of chronic bronchitis and
Study objectives: To demonstrate equivalence in the clinical efficacy of telithromycin vs clarithromycin treatment of outpatients with acute exacerbations ...
Effects of 24 weeks of lansoprazole therapy on asthma symptoms, exacerbations, quality of life, and pulmonary function in adult asthmatic patients with
Background: Difficult-to-control asthma has been associated with gastroesophageal acid reflux. Acid-suppressive treatment has been inconsistent in improving ...
Pharmacologic agents associated with QT interval prolongation
KEY POINTS Diverse classes of medications are associated with QT interval prolongation and expose patients to the risk of potentially fatal ventricular ...
Assessment of QT/QTc Interval Prolongation in Clinical Trials: A Regulatory Perspective*, The
Excessive prolongation of the QT/QTc interval creates an electrophysiological environment that predisposes the myocardium to torsade de pointes, a polymorphic ...
Lichen nitidus treated with topical tacrolimus
Abstract A 32-year-old Philippino male presented to the clinic with a penile rash of 2 months duration. The rash was diagnosed as lichen nitidus and ...

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