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Anastrozole

Anastrozole (Arimidex) is a drug used to treat breast cancer in post-menopausal women. It is used in both adjuvant therapy (i.e. following surgery) and in metastatic breast cancer. It works by decreasing the amount of estrogen that the body makes. more...

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Anastrozole belongs in the class of drugs known as aromatase inhibitors. It inhibits the enzyme aromatase, which is responsible for converting androgens (produced by women in the adrenal glands) to oestrogen.

The ATAC (Arimidex, Tamoxifen, Alone or in Combination) trial represents a long-term follow-up study of 9366 women with localized breast cancer who received either anastrozole or/and tamoxifen. After more than 5 years the group that received anastrozole had significantly better clinical results than the tamoxifen group. The trial suggested that anastrozole is the preferred medical therapy for postmenopausal women with localized breast cancer that is estrogen receptor positive.

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Anastrozole seen as first-line breast Ca therapy: anastrozole showed significant advantages over tamoxifen in time to local and distant recurrence.(Women's ... : An article from: Family Practice News $5.95 Aromatase Inhibitors Topple Tamoxifen In Controlling Advanced Breast Cancer.(Brief Article) : An article from: Family Practice News $5.95
Switch to aromatase inhibitor improves breast ca survival.(Women's Health) : An article from: Internal Medicine News $5.95

Anastrozole deemed cost-effective
SAN ANTONIO -- Anastrozole is a costeffective alternative to generic tamoxifen for primary adjuvant therapy in postmenopausal women with early-stage ...
Study: 5 years of anastrozole more effective than tamoxifen in breast Ca
SAN ANTONIO -- Five years of the aromatase inhibitor anastrozole has now replaced tamoxifen as the endocrine therapy of choice for primary adjuvant therapy of women with hormone receptor-positive e
Anastrozole vs. tamoxifen for treating breast cancer - Tips from Other Journals - Arimidex vs. tamoxifen
Among women with hormone-receptor-positive breast cancer, the odds of recurrence or death are reduced by 47 and 26 percent, respectively, after five ...
Anastrozole effective for newly diagnosed breast cancer - Adjunctive treatment
Anastrozole was effective and well tolerated for adjuvant treatment of early, hormone-sensitive breast cancer in postmenopausal patients in a large, ...
Anastrozole beats Tamoxifen for early breast cancer: Anastrozole reduced disease recurrence risk by 17%, compared with tamoxifen - Study of 9,366 Women
SAN ANTONIO -- The aromatase inhibitor anastrozole is markedly more effective and better tolerated than tamoxifen for adjunctive therapy in postmenopausal ...
Enzyme fighter works as well as tamoxifen - anastrozole shown to be more effective against estrogen-dependent breast cancer than tamoxifen - Brief Article
A drug that physicians usually prescribe for breast cancer only after the front-line tumor fighter tamoxifen has lost its punch works just as well as ...
Tamoxifen alone discouraged as adjuvant Tx
HOLLYWOOD, FLA. -- An aromatase inhibitor, either alone or after tamoxifen therapy, is better than tamoxifen alone for the long-term prevention of breast ...
Endocrine disorders may be overlooked during cancer Tx
WASHINGTON -- The focus on short-term goals during cancer treatment can overshadow care for diabetes and other endocrine disorders that patients may ...

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