Adapalene chemical structure
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Adapalene

Adapalene is a chemical compound that is primarily used as a topical treatment for acne. It is a retinoid, meaning it is chemically similar to Vitamin A, and is currently sold by Galderma Laboratories under the trade name Differin in many different forms. In pure form, adapalene is a white to off white powder that is insoluble in water. more...

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History

Adapalene was approved in 1996 by the FDA for use in the treatment of acne.

Available forms

Adapalene is available in four different forms: gel, solution, pledglets and cream.

Indications

Adapalene is indicated for acne vulgaris.

Pharmacodynamics

Adapalene in small concentrations is a moderator of cellular differentiation, keratinization, and inflammatory processes. The exact mode of action of adapalene is unknown.

Pharmacokinetics

Adapalene is applied topically to the skin, and its absorption through this medium is very low. Only trace amounts of adapalene have been found in the plasma of chronically treated patients.

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Balance efficacy and tolerability when selecting topical retinoids for acne.(Skin Disorders) : An article from: Family Practice News $5.95 The efficacy and safety of adapalene gel 0.3% in the treatment of acne vulgaris: a randomized, multicenter, investigator-blinded, controlled comparison ... from: Journal of Drugs in Dermatology $5.95
Safety and efficacy of adapalene gel 0.1% in acne vulgaris: results of a post-marketing surveillance study.(Study) : An article from: Indian Journal of Dermatology, Venereology and Leprology $5.95

The efficacy and safety of adapalene gel 0.3% in the treatment of acne vulgaris: a randomized, multicenter, investigator-blinded, controlled comparison
The Efficacy and Safety of Adapalene Gel 0.3% in the Treatment of Acne Vulgaris: A Randomized, Multicenter, Investigator-Blinded, Controlled Comparison ...
Cumulative irritation potential of adapalene 0.1% cream and gel compared with tretinoin microsphere 0.04% and 0.1%
Cumulative Irritation Potential of Adapalene 0.1% Cream and Gel Compared with Tretinoin Microsphere 0.04% and 0.1% Dosik JS, MD, et al. Cutis. 2005;75(4):238-243.
Tazarotene cream versus adapalene cream in the treatment of facial acne vulgaris: a multicenter, double-blind, randomized, parallel-group study
Abstract A multicenter, double-blind, randomized, parallel-group trial compared tazarotene 0.1% cream with adapalene 0.1% cream, once daily for 12 ...
Assessment of adapalene gel for the treatment of actinic keratoses and lentiginess a randomized trial - Washington Whispers
The purpose of this article was to determine the safety and efficacy of adapalene gel in the treatment of actinic keratoses and solar lentigines. A prospective two-center, randomized, controlled,
Both topical isotretinoin and adapalene are efficacious in the treatment of acne - Washington Whispers - Brief Article
This study compares the efficacy and tolerability of adapalene gel 0.1% and isotretinoin gel 0.05% in the treatment of acne vulgaris of the face. This ...
Adapalene for Acne
Adapalene was as effective as tretinoin for the treatment of mild to moderate acne, while producing significantly less irritation, Dr. W.J. Cunliffe ...
Adapalene for Acne - Brief Article
Adapalene was as effective as tretinoin for treating mild to moderate acne and produced less irritation, Dr. W.J. Cunliffe said in a poster session at the annual meeting of the American Academy of
Adapalene Over Retin A
Adapalene gel worked just as quickly and effectively as Retin A Micro in clearing acne, but it caused less dryness, stinging, burning, erythema, and ...

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