Adapalene chemical structure
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Adapalene

Adapalene is a chemical compound that is primarily used as a topical treatment for acne. It is a retinoid, meaning it is chemically similar to Vitamin A, and is currently sold by Galderma Laboratories under the trade name Differin in many different forms. In pure form, adapalene is a white to off white powder that is insoluble in water. more...

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History

Adapalene was approved in 1996 by the FDA for use in the treatment of acne.

Available forms

Adapalene is available in four different forms: gel, solution, pledglets and cream.

Indications

Adapalene is indicated for acne vulgaris.

Pharmacodynamics

Adapalene in small concentrations is a moderator of cellular differentiation, keratinization, and inflammatory processes. The exact mode of action of adapalene is unknown.

Pharmacokinetics

Adapalene is applied topically to the skin, and its absorption through this medium is very low. Only trace amounts of adapalene have been found in the plasma of chronically treated patients.

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Both topical isotretinoin and adapalene are efficacious in the treatment of acne - Washington Whispers - Brief Article
From Journal of Drugs in Dermatology, 12/1/02

This study compares the efficacy and tolerability of adapalene gel 0.1% and isotretinoin gel 0.05% in the treatment of acne vulgaris of the face. This was a randomized, open-label clinical trial involving 80 patients who were instructed to apply adapalene gel 0.1% or isotretinoin gel 0.05% once daily over a 12-week treatment period. Efficacy determination included non-inflammatory and inflammatory lesion counts by the investigator and global evaluation of improvement. Cutaneous tolerance was assessed by determining erythema, scaling and burning with pruritus.

Both topical treatments improved facial acne. Adapalene gel had a greater reduction in lesion counts overall but this was not statistically significant. Adapalene gel was significantly better tolerated than isotretinoin gel during the whole treatment period. This study shows that topical adapalene gel and isotretinoin gel have equal efficacy in treating facial acne but that adapalene may have better tolerability.

Ioannides D, Katsambas A. Topical adapalene gel 0.1% vs. isotretinoin gel 0.05% in the treatment of acne vulgaris: a randomized open-label clinical trial. Br J Dermatol 2002 Sep; 147(3):523-7.

COPYRIGHT 2002 Journal of Drugs in Dermatology
COPYRIGHT 2003 Gale Group

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