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Arimidex

Anastrozole (Arimidex) is a drug used to treat breast cancer in post-menopausal women. It is used in both adjuvant therapy (i.e. following surgery) and in metastatic breast cancer. It works by decreasing the amount of estrogen that the body makes. more...

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Anastrozole belongs in the class of drugs known as aromatase inhibitors. It inhibits the enzyme aromatase, which is responsible for converting androgens (produced by women in the adrenal glands) to oestrogen.

The ATAC (Arimidex, Tamoxifen, Alone or in Combination) trial represents a long-term follow-up study of 9366 women with localized breast cancer who received either anastrozole or/and tamoxifen. After more than 5 years the group that received anastrozole had significantly better clinical results than the tamoxifen group. The trial suggested that anastrozole is the preferred medical therapy for postmenopausal women with localized breast cancer that is estrogen receptor positive.

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Arimidex gets green light as treatment for breast cancer - wins FDA approval - Brief Article
From Drug Store News, 10/16/00

The FDA has approved AstraZeneca's breast cancer treatment Arimidex (anastrozole) as a new treatment option for postmenopausal women first diagnosed with advanced or locally advanced breast cancer whose cancers are hormone receptive.

Arimidex is the first aromatase inhibitor to be approved for first-line treatment in the United States. Arimidex previously was only approved for use after disease progression following tamoxifen treatment. AstraZeneca reported that two pivotal studies found that Arimidex was as effective and well tolerated as tamoxifen when prescribed at the time of diagnosis for women with advanced breast cancer.

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