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Oxytetracycline

Oxytetracycline is known as a broad-spectrum antibiotic due to its activity against such a wide range of infections.It was the second of the Tetracyclines to be discovered. It was first found near Pfizer laboratories in a soil sample yielding the soil bacillus, Streptomyces rimosus. In 1953, a celebrated American biochemist, Robert B Woodward, son of a Scottish immigrant woman, worked out the chemical structure of Oxytetracycline, enabling Pfizer to mass produce the drug under the tradename, Terramycin. This discovery by Woodward was a major advancement in Tetracycline research and eventually lead to the synthesis of an Oxytetracycline derivative, Doxycycline, probably the most commonly used Tetracycline nowadays. more...

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Application

Oxytetracycline, like other Tetracyclines, is used to treat many infections common and rare. These include infections of the respiratory tract, sinuses, middle ear, skin and flesh, urinary tract, intestines and also Gonorrhoea, especially in patients allergic to Beta-lactams and Macrolides, however, as with other Tetracyclines, its use for these indications is less popular than it once was due to widespread resistance development in the causative organisms.

Oxyteracycline can also used to treat rarer conditions such as Anthrax, Plague, Brucellosis, Tularaemia, Cholera, Legionnaire's disease and Rickettsial infections. It is frequently used against Non Specific urethritis, Trachoma, Psittacosis, Borreliosis, Lymphogranuloma venereum and infections involving Chlamydia, Mycoplasma or Ureaplasma.

It is often used to treat Spirochaetal infection and Clostridial wound infection in patients sensitive to Penicillin.

Oxytetracycline has been used for very severe acne.

The standard dose is 250-500mg six hourly by mouth. In particularly severe infections this dose may be increased accordingly. Occasionally, Oxytetracycline is given by intramuscular injection or topically in the form of cream or eyedrops.

Other Applications

Oxytetracycline is used to control the outbreak of American Foulbrood and European Foulbrood in honeybees.

Ingredients

Often administered orally in the form of 250mg Tablets. Oxytetracycline tablets contain magnesium, stearate, maize starch, propylene glycol, colloidal silica, sodium dodecyl sulfate, E104, E110, E171, E463, E464, E553.

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Incidence of mastitis in beef cows after intramuscular administration of oxytetracycline : An article from: Journal of Animal Science $20.00 Efficacy of intramuscular treatment of beef cows with oxytetracycline to reduce mastitis and to increase calf growth : An article from: Journal of Animal Science $20.00
Preventive treatment of bovine brucellosis witth oxytetracycline Use of medicated feed in channel catfish ([Fact sheet])
Oxytetracycline micro-fluorescent comparison of orthodontic retraction into recent and healed extraction sites Teratologic evaluation of oxytetracycline hydrochloride (CAS no. 2058-46-0) in CD-1 mice ;: Laboratory study : February 13, 1981 to July 1, 1981
Oxytetracycline and oxolinic acid as antibacterials in aquaculture: Analysis, pharmacokinetics, and environmental impacts (Acta Academiae Aboensis. Ser. B, Mathematica et physica) A fluorometric method for the quanitative determination of sub-microgram amounts of oxytetracycline in sockeye salmon (Oncorhynchus nerka) fry (FRED reports)
Evaluating the contribution of stocked walleye fry and fingerlings to South Dakota fisheries through mass marking with oxytetracycline (Completion report) Publications and presentations of Arthur R. English

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