Tamoxifen chemical structure
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Tamoxifen

Tamoxifen is an oral selective estrogen receptor modulator which is used in breast cancer treatment, and is currently the world's largest selling breast cancer treatment. It is used for the treatment of early and advanced breast cancer in pre- and post-menopausal women. It is also approved by the FDA for the reduction of the incidence of breast cancer in women at high risk of developing the disease. It has been further approved for the reduction of contralateral (in the opposite breast) breast cancer. more...

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Tamoxifen was invented by ICI Pharmaceuticals (now AstraZeneca) and is sold under the brand names Nolvadex, Istubal, and Valodex. It is also available as a generic drug in a number of countries. In the United States, the drug was almost always referred by its generic name, even before patent expiration.

4-hydroxytamoxifen

4-hydroxytamoxifen is a form of the drug tamoxifen that is made by the body after taking tamoxifen. It can also be made in the laboratory, and may help decrease breast density. A topical form of 4-hydroxytamoxifen is being studied in breast cancer screening.

Links

  • STAR: a head-to-head comparison of tamoxifen and raloxifene as breast-cancer preventatives

Read more at Wikipedia.org


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Tamoxifen and Breast Cancer : Second edition $1.49 Post-tamoxifen letrozole may cut breast ca risk: more than 5,000 women studied. (cancer).(Clinical Rounds) : An article from: Internal Medicine News $5.95
Tamoxifen: New Hope in the Fight Against Breast Cancer $0.01 Light at the end of the tunnel? (tamoxifen may help to prevent breast cancer) : An article from: Medical Update $5.95
Ultrasonography in the Assessment of Ovarian and Tamoxifen-Associated Endometrial Pathology (Acta Biomedica Lovaniensia , No 163) $34.85 Tamoxifen prevents breast cancers--at a price. (Study of More than 7,000 Women). : An article from: Family Practice News $5.95
Balancing Tamoxifen's Benefits, Risks. : An article from: Family Practice News $5.95 Aromatase Inhibitors Topple Tamoxifen In Controlling Advanced Breast Cancer.(Brief Article) : An article from: Family Practice News $5.95
Sex hormones and the selective estrogen receptor modulator tamoxifen modulate weekly body weights and food intakes in adolescent and adult rats : An article from: The Journal of Nutrition $20.00 Anastrozole bests tamoxifen in early breast cancer trial: A 17% drop in risk of disease recurrence was seen in postmenopausal patients. (ATAC Study of ... : An article from: Internal Medicine News $5.95

The trouble with tamoxifen: a drug can halve your risk of developing breast cancer. Or, in a small number of cases, it can have potentially fatal side
Before Helene Wilson reached her 45th birthday she was warned in no uncertain terms about her chances of getting breast cancer. "You're a walking ...
Prevention of breast cancer with tamoxifen
Decisions regarding tamoxifen (Nolvadex) use in the prevention of breast cancer are complex. Investigators in the Breast Cancer Prevention Trial, a large nationwide study, found that tamoxifen prop
Use of letrozole after tamoxifen for breast cancer
The estrogen-receptor blocker tamoxifen has been shown to approximately halve the cancer recurrence rate when taken for five years after surgery for ...
Does tamoxifen prevent breast cancer? - Tips from Other Journals - Author Abstract
Studies of tamoxifen in the prevention of breast cancer have had mixed results. Cuzick and colleagues reviewed data from all available randomized trials ...
NCI study: more than 2 million U.S. women could benefit from tamoxifen - Research Notebook - National Cancer Institute
A new analysis of U.S. cancer data by the National Cancer Institute (NCI) indicates that more than 2 million American women could benefit from taking ...
Can tamoxifen reduce the risk of breast cancer? - Tips from Other Journals
Use of tamoxifen has reduced the rate of new cancers in breast cancer survivors by about 50 percent, leading to speculation that this drug could provide ...
Benefits of tamoxifen for breast cancer prevention do not always outweigh overall risks - Patient-Oriented Evidence that Matters - Abstract
IBIS Investigators First results from the International Breast Cancer Intervention Study (IBIS-I): a randomized prevention trial. Lancet 2002; 360:817 ...
Anastrozole vs. tamoxifen for treating breast cancer - Tips from Other Journals - Arimidex vs. tamoxifen
Among women with hormone-receptor-positive breast cancer, the odds of recurrence or death are reduced by 47 and 26 percent, respectively, after five ...

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