Molecular structure of troglitazone
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Troglitazone

Troglitazone (Rezulin®, Resulin® or Romozin®) is a member of the drug class of the thiazolidinediones. It was introduced in the late 1990s but turned out to be associated with an idiosyncratic reaction leading to drug-induced hepatitis. It was withdrawn from the USA market on 21 March 2000, and from other markets soon afterwards. more...

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Troglitazone, like the other thiazolidinediones (pioglitazone and rosiglitazone), works by activating PPARs (peroxisome proliferator-activated receptors). Troglitazone is a ligand to both PPARα and - more strongly - PPARγ. Troglitazone also contains an α-tocopheroyl moiety, potentially giving it vitamin E-like activity in addition to its PPAR activation. It has been shown (Aljada et al) to reduce inflammation: troglitazone use was associated with a decrease of nuclear factor kappa-B (NFκB) and a concomitant increase in its inhibitor (IκB). NFκB is an important cellular transcription regulator for the immune response.

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New 'Glitazones' Appear Safer for Liver Than Rezulin. : An article from: Family Practice News $5.95 Sequence variation in PPARG may underlie differential response to troglitazone. : An article from: Diabetes $5.95
Prevention of type 2 diabetes with troglitazone in the Diabetes Prevention Program.(Pharmacology & Therapeutics) : An article from: Diabetes $5.95 Diabetes Drug Forces Differentiation of Ca Cells. : An article from: Family Practice News $5.95
Rosiglitazone: at 10 years, no liver toxicity seen: experience in more than 7,000 patients shows the agent to be free of troglitazone's side effect.(Metabolic ... : An article from: Family Practice News $5.95 Evaluation of the hepatotoxic potential of xenobiotics: Troglitazone and bosentan inhibit the hepatobiliary transport of taurocholate : (Dissertation) $55.00
Troglitazone improves whole-body insulin resistance and skeletal muscle glucose use in type II diabetic patients : An article from: The Journal of Nuclear Medicine $20.00

Company played down drug's risks, report says - Warner-Lambert, troglitazone - News
Warner-Lambert played down the potentially fatal risks associated with troglitazone during the approval process and received help from federal drug regulators in pushing the drug towards marketing
Troglitazone Has Been Withdrawn from the Market - Rezulin
After a request from the FDA on March 21, the manufacturer of troglitazone (Rezulin), a drug used in the treatment of type 2 diabetes mellitus (formerly ...
Troglitazone—Primary Prevention For Type 2 Diabetes? - Brief Article - Statistical Data Included
Troglitazone has been found effective in improving glycemic control in type 2 diabetics. It appears to enhance peripheral insulin sensitivity in diabetics ...
Change to Troglitazone Label
For the fourth time since its approval, troglitazone's labeling has been changed to reflect the potential for serious and sometimes fatal liver toxicity.
Troglitazone or Metformin in Combination with Sulfonylureas for Patients with Type 2 Diabetes?
BACKGROUND. Combination oral therapy is often used to control the hyperglycemia of patients with type 2 diabetes. We compared the effectiveness of metformin ...
Diabetes drug stirs cancer confusion - troglitazone and colon cancer - Brief Article
New research has offered hope that troglitazone, a widely prescribed diabetes drug, could become a new colon cancer therapy, but some scientists also ...
Troglitazone recommended for second-line combination use
An FDA advisory panel has recommended that troglitazone (Rezulin) be used only as a second-line diabetes therapy in combination with other diabetes drugs ...
Effects of berberine on glucose metabolism in vitro
Yin J, Hu R, Chen M, et al. Metabolism 2002;51:1439-1443. The action of berberine was compared with metformin and troglitazone (TZD) with regard to ...

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