Oxcarbazepinechemical structure
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Trileptal

Oxcarbazepine (Marketed as Trileptal® by Novartis) is an anticonvulsant and mood stabilizing drug, used primarily in the treatment of epilepsy and bipolar disorder. more...

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Oxcarbazepine is structurally a derivative of carbamazepine, adding a extra oxygen atom to the benzylcarboxamide group. This difference helps reduce the impact on the liver of metabolizing the drug, and also prevents the serious forms of anemia occasionally associated with carbamazepine. Aside from this reduction in side effects, it is thought to have the same mechanism as carbamazepine - sodium channel inhibition - and is generally used to treat the same conditions.

Side effects

Oxcarbazepine occasionally causes fatigue, nausea, vomiting, headache, dizziness, drowsiness, and blurred or double vision. It can cause hyponatremia, so blood sodium levels should be tested if the patient complains of severe fatigue.

History

First synthesized in 1966, it was approved for use as an anticonvulsant in Denmark in 1990. It was approved in all EU countries in 1999 and in the US in 2000.

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Trileptal.(New & Approved) : An article from: Pediatric News $5.95

Novartis launches seizure drug Trileptal - Brief Article
The Food and Drug Administration granted marketing clearance for an oral suspension formulation of Trileptal (oxcarbazepine), an antiepileptic drug developed ...
FDA Approval of Oxcarbazepine - Trileptal
The U.S. Food and Drug Administration (FDA) has approved oxcarbazepine (Trileptal) for the treatment of partial seizures as monotherapy in adults and ...
Epilepsy Rx. offered by Novartis Pharmaceuticals Corp. - Trileptal oxcarbazepine - Brief Article
Trileptal (oxcarbazepine) is indicated as adjunctive therapy or monotherapy for partial seizures in adults and as adjunctive therapy for partial seizures ...
FDA clears Trileptal, first-line monotherapy for epilepsy
The Food and Drug Administration has granted marketing clearance for Novartis Pharmaceuticals' Trileptal (oxcarbazepine) tablets. Trileptal is an antiepileptic ...
Recommendations for prescribing new antiepileptic drugs
Several new antiepileptic drugs (AEDs) are effective in treating selected patients with partial or mixed seizure disorders, but evidence for their efficacy ...
Bipolar disorder - Drugs, Pregnancy, And Lactation
As the use of anticonvulsants to treat bipolar illness has grown over the past decade, so has the number of women successfully treated with these medications ...
Three Studies Support Long-term Use of Trileptal-R- in Patients with Partial Seizures
Business Editors/Health/Medical Writers EAST HANOVER, N.J.--(BUSINESS WIRE)--Dec. 10, 2002 The antiepileptic drug (AED) Trileptal (R) (oxcarbazepine, ...
Novartis shifts pricing, availability - Brand Watch - medications - Brief Article
Novartis shifts pricing, availability. (Brand Watch).(medications)

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