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Tobramycin

Tobramycin sulfate is an aminoglycoside antibiotic used to treat various types of bacterial infections, particularly Gram-negative infections. more...

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Mechanism of action

Tobramycin works by binding to a site on the bacterial ribosome, causing the genetic code to be misread.

Administration

Like all aminoglycosides, tobramycin does not pass the gastro-intestinal tract, so for systemic use it can only be given intravenously or intramuscularly. This formulation for injection is branded Nebcin®. Patients with cystic fibrosis will often take an inhalational form (Tobi®) for suppression of Pseudomonas aeruginosa infections. Tobramycin is also combined with dexamethasone as an opthalmic solution (TobraDex®).

Side effects

Like other aminoglycosides, tobramycin can cause deafness or a loss of equilibrioception in genetically susceptible individuals. These individuals have a normally harmless mutation in their DNA, that allows the tobramycin to affect their cells. The cells of the ear are particularly sensitive to this.

Tobramycin can also be highly toxic to the kidneys, particularly if multiple doses accumulate over a course of treatment.

For these reasons, when tobramycin is given parenterally, it is usually dosed by body weight. Various formulae exist for calculating tobramycin dosage. Also serum levels of tobramycin are monitored during treatment.

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Chiron announces settlement of patent dispute over tobramycin solution. : An article from: BIOTECH Patent News $5.95 Tobramycin Profile (Sensors) $62.07
Inhaled Tobramycin. : An article from: Pediatric Nursing $5.95 Tobramycin - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References $34.95
Gentamicin and tobramycin clinical pharmacokinetics and nephrotoxicity aspects on assay techniques (Scandinavian journal of infectious diseases : Supplementum) Round-table Discussion on Gentamicin and Tobramycin: [papers and discussion] (International Congress and symposium series - Royal Society of Medicine ; no. 4)

The efficacy and safety of meropenem and tobramycin vs ceftazidime and tobramycin in the treatment of acute pulmonary exacerbations in patients with cystic
Background: Cystic fibrosis (CF) is characterized by chronic pulmonary infection with acute pulmonary exacerbations (APEs) requiring IV antibiotic treatment.
Inhaled tobramycin: not just for cystic fibrosis anymore?
The use of inhaled medications for the treatment of pulmonary diseases is an attractive concept. In theory, this mode allows for the delivery of a high ...
A pilot study of the safety and efficacy of tobramycin solution for inhalation in patients with severe bronchiectasis
Study objective: To evaluate the efficacy and safety of tobramycin solution for inhalation (TSI) in patients with severe bronchiectasis. Design: Open-label ...
Inhalation of a dry powder tobramycin PulmoSphere formulation in healthy volunteers - preliminary reports
Study objectives: To evaluate the efficiency and reproducibility of pulmonary delivery of an investigational tobramycin PulmoSphere formulation (PStob) ...
Efficiency of pulmonary administration of tobramycin solution for inhalation in cystic fibrosis using an improved drug delivery system - clinical investigations
Study objectives: To determine whether tobramycin solution for inhalation (TSI) can be administered safely and more efficiently with a new-generation ...
Evaluation of bronchial constriction in children with cystic fibrosis after inhaling two different preparations of tobramycin - clinical investigations
Objectives: This randomized, double-blind, cross-over study evaluated the risk of bronchoconstriction with two preparations of inhaled tobramycin in ...
Pharmacokinetics and bioavailability of aerosolized tobramycin in cystic fibrosis
Study objectives: To describe the pharmacokinetics and bioavailability of inhaled tobramycin (TOBI; Chiron Corporation; Seattle, WA), 300-mg dose, delivered ...
Long-term benefits of inhaled tobramycin in adolescent patients with cystic fibrosis - clinical investigations - Statistical Data Included
Study objective: To determine the effect of long-term suppression of Pseudomonas aeruginosa on lung function and other clinical end points in adolescent ...

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