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Ticarcillin

Ticarcillin, also known as Timentin, is a Beta-lactam antibiotic similar to penicillin. It is often used as an injectable antibiotic for the treatment of gram negative bacteria, and is especially effective against Pseudomonas aeruginosa. Its antibiotic properties arise from its ability to prevent cross-linking of peptidoglycan during cell wall synthesis when the bacteria tries to divide, causing death. It will not treat viruses, including the flu. Because it is similar in structure to penicillin, it should not be used by anyone with allergies to any penicillin-related antibiotic. more...

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Many bacteria have developed a resistance to this antibiotic by producing beta-lactamase, which inactivates it. Therefore, all modern ticarcillin includes clavulanic acid, an inbibitor of these enzymes.

In molecular biology, ticarcillin is used to as an alternative to ampicillin to test the uptake of marker genes into bacteria. It prevents the appearance of satellite colonies that occur when ampicillin breaks down in the media. It is also used in plant molecular biology to kill agrobacterium, which is used to deliver genes to plant cells.

Chemically, ticarcillin is C15H16N2O6S2 (CAS number 34787-01-4). It is provided as a white or pale yellow powder. It is highly soluble in water, but should only be dissolved immediately prior to use to prevent degradation.

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Ticarcillin (BRL 2288): Papers presented at an International Symposium on Ticarcillin held at Bürgenstock, Switzerland, on 16th September 1977 (International congress series)

Susceptibility of clinical isolates of Bacteroides fragilis group strains to cefoxitin, cefoperazone and ticarcillin/clavulanate
SUMMARY A total of 40 strains of the B. fragilis group was isolated from clinical specimens in two hospital centers in Fortaleza from 1993 to 1997. The ...
Salmonella and Campylobacter spp. in northern elephant seals, California
Campylobacter and Salmonella spp. prevalence and antimicrobial drug sensitivity were determined in northern elephant seals that had not entered the water and seals that were stranded on the Califor
Clinical characteristics and risk factors of mortality among severe burn patients with isolates of vancomycin-resistant enterococci
PURPOSE: Vancomycin-resistant enterococci (VRE) are multi-drug resistant organisms that have emerged as important nosocomial pathogens in recent years.
Vibrio metschnikovii pneumonia
To the Editor: Vibrio metschnikovii is a gram-negative, oxidase-negative bacillus. This species was isolated in 1981 from blood culture of an 82-year-old ...
Penetration of gentamicin into the alveolar lining fluid of critically ill patients with ventilator-associated pneumonia
Study objectives: To estimate the penetration of gentamicin into lung tissue by measuring its concentrations in alveolar lining fluid (ALF) and blood ...
Penicillin Skin Testing: A 20-Year Study at the West Los Angeles Veterans Affairs Medical Center
Penicillin (PCN) may cause a reaction in up to 10% of the population. No study has examined PCN skin testing longitudinally over a 20-year period. A total ...
Early Bactericidal Activities of Rifampin and Rifapentine in Pulmonary Tuberculosis, The
Rationale: Comparison of the early bactericidal activity (EBA) of rifapentine and its pharmacokinetics with those of rifampin to determine the cause of ...
Effects of Segregation on an Epidemic Pseudomonas aeruginosa Strain in a Cystic Fibrosis Clinic
The detection of a clonal Pseudomonas aeruginosa strain in 21% of children attending a cystic fibrosis clinic during 1999, which may have led to a worse ...

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