Clorazepate (brand name: Tranxene®) is a member of the group of drugs called benzodiazepines. Benzodiazepines are prescribed by general practitioners and psychiatrists in the treatment of anxiety disorders and insomnia. They may also be prescribed as anticonvulsants and muscle relaxants. In the twenty-first century, clorazepate is principally prescribed in the treatment of alcohol withdrawal and epilepsy, though of course it is a useful anxiolytic because of its long half-life. The normal starting dosage range of clorazepate is 15-60 mg 2-4 x per day. Dosages as high as 90-120 mg per day may be used in the treatment of acute alcohol withdrawal. Clorazepate is available in 3.75, 7.5, and 15 mg capsules or tablets. more...
Clorazepate SD (controlled release) is available in 11.25 and 22.5 mg tablets. Clorazepate SD is only prescribed when the patient has become adjusted to a certain dosage, and is taken once a day. Clorazepate is available in generic form. Clorazepate begins to act on the central nervous system within one or two hours, and its effects may be felt for an entire day or longer in some individuals. It is contraindicated for those with impaired renal or hepatic function. Clorazepate is listed under Schedule IV of the Controlled Substances Act and is as highly addictive as the other benzodiazepines. Clorazepate was approved for use in the United States by the Food and Drug Administration in 1972.
All sedatives are likely to magnify the effects of Tranxene on the central nervous system. Cimetidine inhibits breakdown of clorazepate, and leads to increased levels of the drug in the system.
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