Oseltamivir chemical structuresynthesis of tamiflu
Find information on thousands of medical conditions and prescription drugs.

Tamiflu

Oseltamivir (pronounced ah sell TAH mih veer) is an antiviral drug used in the treatment and prophylaxis of both influenza A and influenza B. Like zanamivir, oseltamivir is a neuraminidase inhibitor, acting as a transition-state analogue inhibitor of influenza neuraminidase and thereby preventing new viruses from emerging from infected cells. Oseltamivir was the first orally active neuraminidase inhibitor commercially developed. more...

Home
Diseases
Medicines
A
B
C
D
E
F
G
H
I
J
K
L
M
N
O
P
Q
R
S
T
Oxytetracycline
Phentermine
Tacrine
Tacrolimus
Tagamet
Talbutal
Talohexal
Talwin
Tambocor
Tamiflu
Tamoxifen
Tamsulosin
Tao
Tarka
Taurine
Taxol
Taxotere
Tazarotene
Tazobactam
Tazorac
Tegretol
Teicoplanin
Telmisartan
Temazepam
Temocillin
Temodar
Temodar
Temozolomide
Tenex
Teniposide
Tenoretic
Tenormin
Tenuate
Terazosin
Terbinafine
Terbutaline
Terconazole
Terfenadine
Teriparatide
Terlipressin
Tessalon
Testosterone
Tetrabenazine
Tetracaine
Tetracycline
Tetramethrin
Thalidomide
Theo-24
Theobid
Theochron
Theoclear
Theolair
Theophyl
Theophyl
Theostat 80
Theovent
Thiamine
Thiomersal
Thiopental sodium
Thioridazine
Thorazine
Thyroglobulin
Tiagabine
Tianeptine
Tiazac
Ticarcillin
Ticlopidine
Tikosyn
Tiletamine
Timolol
Timoptic
Tinidazole
Tioconazole
Tirapazamine
Tizanidine
TobraDex
Tobramycin
Tofranil
Tolazamide
Tolazoline
Tolbutamide
Tolcapone
Tolnaftate
Tolterodine
Tomoxetine
Topamax
Topicort
Topiramate
Tora
Toradol
Toremifene
Tracleer
Tramadol
Trandate
Tranexamic acid
Tranxene
Tranylcypromine
Trastuzumab
Trazodone
Trenbolone
Trental
Trest
Tretinoin
Triacetin
Triad
Triamcinolone
Triamcinolone hexacetonide
Triamterene
Triazolam
Triclabendazole
Triclosan
Tricor
Trifluoperazine
Trilafon
Trileptal
Trimetazidine
Trimethoprim
Trimipramine
Trimox
Triprolidine
Triptorelin
Tritec
Trizivir
Troglitazone
Tromantadine
Trovafloxacin
Tubocurarine chloride
Tussionex
Tylenol
Tyrosine
U
V
W
X
Y
Z

Oseltamivir is a prodrug (usually administered as phosphate); it is hydrolysed hepatically to the active metabolite, the free carboxylate of oseltamivir (GS4071).

Oseltamivir was developed by Gilead Sciences and is currently marketed by Hoffmann-La Roche (Roche) under the trade name Tamiflu®.

With increasing fears about the potential for a new influenza pandemic, oseltamivir has received substantial media attention. Production capacity is limited, and governments are stockpiling the drug.

Technical information

Indications and dosage

Roche recommendations in the United States

Tamiflu is available from Roche in 75mg capsules and as a powder for aqueous suspension of 12 mg/mL. According to prescription information by Roche for the United States, Tamiflu usage is indicated for both the treatment and prophylaxis of influenza at the following dosages.

  • Tamiflu is indicated for the treatment of influenza in patients 1 year and older who have had symptoms for no more than two days. For influenza treatment, the standard dosage for patients 13 years and older is 75 mg twice daily for five days. Dosage for children is by weight.
  • Tamiflu is indicated for prophylaxis of influenza either during a community outbreak or following close contact with an infected individual. Standard dosage is 75 mg once daily for patients aged 13 and older, which has been shown to be safe and effective for up to six weeks. Safety and efficacy for prophylaxis has not been established for patients under 13 years old.

The above treatment regimes are based upon studies of normal human influenza.

Dosage for avian flu

Peter Hobby (of the World Health Organization) has suggested that Vietnam should investigate and test a higher dosage and longer treatment with Tamiflu for patients with avian influenza. Doctors in Vietnam concur, noting that

t least in some patients with influenza A (H5N1) virus infection, treatment with the recommended dose of oseltamivir incompletely suppresses viral replication. Besides allowing the infection to proceed, such incomplete suppression provides opportunities for drug resistance to develop. (de Jong et al. 2005)

Co-administration with probenecid

It has been suggested that co-administration of oseltamivir with another drug called probenecid could dramatically extend the world's limited supply of oseltamivir. Probenecid reduces excretion of oseltamivir's active metabolite. 500 mg of probenecid given every six hours doubles oseltamivir's maximum blood concentration and also doubles the time that oseltamivir stays in the blood, multiplying a patient's overall exposure to the drug 2.5-fold. Probenecid was used in similar fashion during World War II to extend limited supplies of penicillin. The evidence for this interaction comes from a 2002 study by Roche (Hill et al. 2002), but was publicized only in October 2005 by a doctor who had reviewed the data (Butler 2005).

Read more at Wikipedia.org


[List your site here Free!]


2006 If the Bird Flu Pandemic Strikes: Crucial Survival and Medical Data about Influenza, Vaccines, Tamiflu and other Drugs - Avian Flu and the H5N1 Virus (CD-ROM) $19.95 2006 Complete Guide to Bird Flu and Killer Influenza Pandemics – Drugs, Tamiflu, Avian Flu Pandemic Preparations, Vaccines, Medical Guidelines and Research, H5N1 Virus (CD-ROM) $19.95
21st Century Patient’s Guide to Bird Flu and Pandemic Influenza – H5N1 Avian Flu, Clinical and Public Health Guidelines, Drugs, Tamiflu, Vaccines, CDC Data $19.95 2006 Essential Guide to Influenza: Medical Data about Influenza, Vaccines, Tamiflu and other Drugs, Avian Flu and the H5N1 Virus, Government Documents and Data (Ring-bound) $29.95
Flu Drug Cuts Rate of Post-Flu Otitis Media.(Brief Article) : An article from: Family Practice News $5.95 Tamiflu. : An article from: Family Practice News $5.95
Roche to ramp up production of flu-fighting drug Tamiflu : An article from: Boulder County Business Report $10.00 Roche may hike Tamiflu drug production : An article from: Boulder County Business Report $10.00
21st Century Collection Centers for Disease Control Emerging Infectious Diseases (EID) Guide to Bird Flu and Pandemic Influenza: H5N1 Avian Flu, Drugs, Tamiflu, Vaccines $19.95 New Drugs Predicted to Transform Flu Management. : An article from: Family Practice News $5.95

Roche limits Tamiflu supplies in China to government
HONG KONG, Nov. 8 Kyodo Swiss pharmaceuticals giant Roche revealed Tuesday the supply of flu treatment Tamiflu in China is limited to the government ...
Roche halts Tamiflu supply to H.K. pharmacies
HONG KONG, Nov. 3 Kyodo Flu treatment Tamiflu's Swiss maker Roche has stopped supplying the drug to Hong Kong pharmacies and private doctors to reserve ...
Tamiflu's Road Remedy - Brief Article
For marketers of seasonal products in a category as competitive and unpredictable as cold and flu remedies, it's crucial to be first. Just ask the folks ...
FDA Approves the Use of Oseltamivir in Children - use of Tamiflu for children with influenza complications
The U.S. Food and Drug Administration (FDA) has approved a new pediatric indication for oseltamivir (Tamiflu). The medication may now be used for the ...
Letters to the Editor - Lyme disease prevention and treatment; Tamiflu for the treatment of influenza A and B; rhabdomyolysis caused by sidlenafil-simvastatin
Complying with AAP Lyme Disease Recommendations To The Editor: American Family Physician published recommendations from the American Academy of Pediatrics ...
Tamiflu
(oseltamivir phosphate, Hociae and Gilead Sciences) An oral antiviral for preventing influenza A and B in adults and children 13 years and older. Previously approved for treating tancomplicated i
Tamiflu
(oseltamivir phosphate, Roche and Gilead Sciences) An oral antiviral for preventing influenza A and B in adults and children 13 years and older. Previously ...
Tamiflu gains preventive indication - for the prevention of influenza - Brief Article
Tamiflu (oseltamivir phosphate) from Roche Pharmaceuticals has been approved for the prevention of influenza in adults and children 13 years and older.

Home Contact Resources Exchange Links ebay