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Temozolomide

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Background

Temozolomide (brand name Temodar®) is an oral alkylating agent used for the treatment of refractory anaplastic astrocytoma -- a type of cancerous brain tumour. A derivative of imidazotetrazine, temozolomide is the prodrug of MTIC (3-methyl-(triazen-1-yl)imidazole-4-carboxamide). Temodar is marketed by Schering Corporation, which also markets other well-known prescription drugs such as Clarinex, Nasonex, Levitra, Cipro, Vytorin, Diprolene, Elocon and Lotrisone.

Indications

  • Glioblastoma multiforme: for the treatment of adult patients with newly diagnosed glioblastoma multiforme concomitantly with radiotherapy and then as manitenance treatment.
  • Anaplastic astrocytoma: for the treatment of adult patients with refractory anaplastic atrocytoma (ie. patients who have experienced disease progression on a drug regimen containing nitrosourea and procarbazine).
  • Unlabeled uses: Metastatic melanoma.

Dosage Forms

Temozolomide is available in the United States in 5mg, 20mg, 100mg, & 250mg capsules.

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Temozolomide - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References $34.95 Brain Ca Drug Slows Progression of Melanoma.(temozolomide)(B rief Article) : An article from: Family Practice News $5.95
Gale Encyclopedia of Cancer : Temozolomide $3.90 Radiotherapy plus temozolomide increases glioblastoma survival.(Pulmonary Medicine) : An article from: Internal Medicine News $5.95
Temozolomide slowed tumors in patients with glioblastoma.(Clinical Round) : An article from: Family Practice News $5.95 CTCL tumor size reduced by temozolomide Tx. (Mycosis Fungoides).(cutaneous T-cell lymphoma, treatment) : An article from: Skin & Allergy News $5.95

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This study is currently recruiting patients. Sponsors and Collaborators. Schering-Plough European Organization for Research and Treatment of Cancer.
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Temozolomide (Temodar) has been granted accelerated approval by the U.S. Food and Drug Administration (FDA) for the treatment of adult patients with ...
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Definition A chemotherapy medicine used to reduce the size of a cancerous tumor and prevent the growth of new cancer cells. In the United ...
Baseline ^sup 11^C-methionine PET reflects the natural course of grade 2 oligodendrogliomas
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DUBLIN, Ireland -- Research and Markets (http://www.researchandmarkets.com/reports/c20845) has announced the addition of Stakeholder Opinions: Primary ...

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