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Terbinafine

Terbinafine hydrochloride, sold as Lamisil tablets in the U.S., is often prescribed for the treatment of onychomycosis of the toenail or fingernail due to dermatophytes (Tinea unguium). more...

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It is also sold as a 1% cream or powder for use on suface infections such as jock itch (Tinea cruris) or athlete's foot (Tinea pedis).

Nail fungus infections live deep under the nail in the nail bed. Surface treatments may not be able to reach it in sufficient amounts, so terbinafine hydrochloride is given orally in tablet form, which is absorbed through the bloodstream to reach the infection; this method can cause hepatotoxicity, or liver damage, as well as other serious side effects, so those taking Lamisil tablets often have blood screenings every month. Many health insurance companies consider these infections to be a cosmetic problem, and either do not cover the cost of the months-long course of Lamisil, which can run into the thousands of dollars, or recommend use of less expensive alternatives like fluconazole.

The tablets contain the synthetic allylamine antifungal compound terbinafine hydrochloride, which is a white fine crystalline powder that is freely soluble in methanol and methylene chloride, soluble in ethanol, and slightly soluble in water. Chemically, it is (E)-N-(6,6-dimethyl-2-hepten-4-ynyl)-N-methyl-1- naphthalenemethanamine hydrochloride. The empirical formula C21H26CIN with a molecular weight of 327.90

  • Active Ingredients: Terbinafine hydrochloride (equivalent to 250 mg base)
  • Inactive Ingredients: Colloidal silicon dioxide, Hydroxypropyl methylcellulose USP, Sodium starch glycolate, Magnesium stearate, Microcrystalline cellulose.

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Terbinafine gets high marks for onychomycosis. (Metaanalysis of Four Trials). : An article from: Internal Medicine News $5.95 The use of terbinafine in the treatment of onychomycosis in adults and special populations: a review of the evidence. : An article from: Journal of Drugs in Dermatology $5.95
Metaanalysis shows terbinafine is tops for clipping toenail onychomycosis. (Most Tolerable Treatment). : An article from: Skin & Allergy News $5.95 Ciclopirox topical solution, 8% combined with oral terbinafine to treat onychomycosis: a randomized, evaluator-blinded study. : An article from: Journal of Drugs in Dermatology $5.95
Lamisil: The Evidence $69.95 Tinea capitis calls for higher terbinafine doses: two-week course.(Rx)(Brief Article) : An article from: Family Practice News $5.95
Try more than 4.5 mg/kg per day of terbinafine. (Tinea Capitis in Children). : An article from: Skin & Allergy News $5.95 Try higher doses of terbinafine for treating tinea capitis in children. (How Much Higher Still Unclear). : An article from: Pediatric News $5.95
Higher doses of terbinafine clear tinea capitis better. (2-Week Course). : An article from: Skin & Allergy News $5.95 Use more than 4.5 mg/kg per day of terbinafine. (Tinea Capitis in Children). : An article from: Family Practice News $5.95

Terbinafine compared to griseofulvin in children with tinea capitis
This study is currently recruiting patients. Sponsored by Novartis. Tinea capitis is a dermatophyte infection of the scalp hair follicles, which occurs ...
Ciclopirox topical solution, 8% combined with oral terbinafine to treat onychomycosis: a randomized, evaluator-blinded study
Abstract This randomized, evaluator-blind, 3-arm parallel, comparator controlled, multicenter pilot study evaluated the safety and efficacy of ciclopirox ...
The use of terbinafine in the treatment of onychomycosis in adults and special populations: a review of the evidence
Abstract Terbinafine is an allylamine with fungicidal activity, first approved for the treatment of onychomycosis in the United Kingdom in the early ...
Double blind, randomised study of continuous terbinafine compared with intermittent itraconazole in treatment of toenail onychomycosis
The antifungal drug terbinafine taken every day for 12 to 16 weeks appears to be more effective in treating onychomycosis than itraconazole taken once a week for the same period. This was the conclusi
Terbinafine Offers Advantages in Tinea Capitis - Brief Article
MIAMI BEACH -- Early experience suggests that terbinafine may eventually replace griseofulvin as the prescription of choice for the treatment of patients ...
In vitro susceptibility testing of ciclopirox, terbinafine, ketoconazole and itraconazole against dermatophytes and nondermatophytes, and in vitro evaluation
Gupta AK, Kohli Y. Br J Dermatol 2003 Aug; 149(2):296-305. The authors set out to determine the in vitro susceptibility of fungal organisms to ciclopirox, ...
Continuous Terbinafine Versus Intermittent Itraconazole For Toenail Onychomycosis
Evans EG, Sigurgeirsson B. Double-blind, randomised study of continuous terbinafine compared with intermittent itraconazole in treatment of toenail onychomycosis. BMJ 1999; 318:1031-5. Clinical q
Serious interaction between warfarin and oral terbinafine - Drug Points
J A Warwick, RJ Con-all, Anticoagulant Clinic, Department of Pharmacy, and Directorate of Medicine, Bristol Royal Infirmary, Bristol BS2 8HW Drug interactions ...

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