Find information on thousands of medical conditions and prescription drugs.

Trimipramine

Trimipramine is an tricyclic antidepressant with sedative and anxiolytic properties. more...

Home
Diseases
Medicines
A
B
C
D
E
F
G
H
I
J
K
L
M
N
O
P
Q
R
S
T
Oxytetracycline
Phentermine
Tacrine
Tacrolimus
Tagamet
Talbutal
Talohexal
Talwin
Tambocor
Tamiflu
Tamoxifen
Tamsulosin
Tao
Tarka
Taurine
Taxol
Taxotere
Tazarotene
Tazobactam
Tazorac
Tegretol
Teicoplanin
Telmisartan
Temazepam
Temocillin
Temodar
Temodar
Temozolomide
Tenex
Teniposide
Tenoretic
Tenormin
Tenuate
Terazosin
Terbinafine
Terbutaline
Terconazole
Terfenadine
Teriparatide
Terlipressin
Tessalon
Testosterone
Tetrabenazine
Tetracaine
Tetracycline
Tetramethrin
Thalidomide
Theo-24
Theobid
Theochron
Theoclear
Theolair
Theophyl
Theophyl
Theostat 80
Theovent
Thiamine
Thiomersal
Thiopental sodium
Thioridazine
Thorazine
Thyroglobulin
Tiagabine
Tianeptine
Tiazac
Ticarcillin
Ticlopidine
Tikosyn
Tiletamine
Timolol
Timoptic
Tinidazole
Tioconazole
Tirapazamine
Tizanidine
TobraDex
Tobramycin
Tofranil
Tolazamide
Tolazoline
Tolbutamide
Tolcapone
Tolnaftate
Tolterodine
Tomoxetine
Topamax
Topicort
Topiramate
Tora
Toradol
Toremifene
Tracleer
Tramadol
Trandate
Tranexamic acid
Tranxene
Tranylcypromine
Trastuzumab
Trazodone
Trenbolone
Trental
Trest
Tretinoin
Triacetin
Triad
Triamcinolone
Triamcinolone hexacetonide
Triamterene
Triazolam
Triclabendazole
Triclosan
Tricor
Trifluoperazine
Trilafon
Trileptal
Trimetazidine
Trimethoprim
Trimipramine
Trimox
Triprolidine
Triptorelin
Tritec
Trizivir
Troglitazone
Tromantadine
Trovafloxacin
Tubocurarine chloride
Tussionex
Tylenol
Tyrosine
U
V
W
X
Y
Z

Pharmacology

Trimipramine's mechanism of action differs from other tricyclic antidepressants. It is only a moderate reuptake inhibitor of norepinephrine, and a weak reuptake inhibitor of serotonin and dopamin. The main effects are due to considerable postynaptic blockage as follows:

  • strong : 5-HT2, Muscarinic, H1, H2, Alpha1
  • moderate : D2
  • weak : 5-HT1, Alpha2

The spectrum of effects (strong antidepressant activity, sedation and anxiolysis) and side-effects (strong anticholinergic and antiadrenergic side-effcts) is the same as with Doxepin. It is also a more effective sedative than Amitriptyline. Trimipramine is the only effective drug against insomnia known so far that does not alter the normal sleep architecture. In particular, it does not suppress REM-sleep. Moreover, dreams are said to brighten during treatment. Its relatively strong antagonistic activity at postsynaptic D2-receptors led to a clinical study trying Trimipramine as atypical neuroleptic. There it exerted good antipsychotic activity with a low incidence of extrapyramidal and other side-effects. But this study encompassed only 28 patients, so the use of Trimipramine as a neuroleptic needs further confirmation and can currently not be recommended. Trimipramine shows also useful activity against chronic pain.

Indications

  • Endogenous and neurotic depression with prominent agitation and anxiety
  • Depressive and non-depressive insomnia (suitable for long-term treatment)
  • Adjunctive therapy of alcohol and opioid withdrawal
  • Chronic pain of malignant and non-malignant origin

Trimipramine is an efficient antidepressant, sedative, and anxiolytic comparable to Doxepin.

Contraindications

absolute :

  • concomittant treatment with MAO-Inhibitors
  • known hypersensitivity to Trimipramine or other Tricyclics
  • acute intoxication with alcohol, sedatives, analgesics and other psychoactive drugs
  • acute Delirum tremens
  • untreated closed angle glaucoma
  • hypertrophy of the prostate with urine retention
  • paralytic ileus

relative :

  • hypertrophy of the prostate without urine retention
  • reduced function of the bone marrow
  • organic brain disorders
  • increased risk of seizures, preexisting epilepsy
  • preexisting cardial damage, particular some arrhythmias (impulse conductive disorders)

Side Effects

See the article on Doxepin. All side-effects of Doxepin are noted also during Trimipramine use with approximately the same frequency and intensity in equivalent doses.

Read more at Wikipedia.org


[List your site here Free!]



How to take an antidepressant: it's no longer enough to treat depression; it's necessary to banish it. What's the best drug for that? It boils down to
fifteen years ago, Prozac launched a revolution. It rendered depression a disorder that was--finally--safely treatable. The torrent of prose hailing ...
Safeguards for children taking antidepressant strengthened
The Food and Drug Administration has announced a strategy to warn patients, their caregivers, and physicians about the possibility of an increased risk ...
SSRI use by tinnitus patients: interactions between depression and tinnitus severity
Abstract Depression is often coincident with chronic tinnitus, and several studies have suggested that antidepressant medications may play a role in relieving tinnitus as well as depression. We c
Low-dose tricyclics effective for depression - Patient Oriented Evidence That Matters: practice recommendations from key studies
Furukawa TA, McGuire H, Barbui C. Meta-analysis of effects and side effects of low dosage tricyclic antidepressants in depression: systematic review.
Depression in the Long-Term Care Setting
Elderly patients living in the nursing home setting are up to five times more likely to have depression, but fewer than one fourth are adequately treated.
Antidepressants Appear Safe During Pregnancy
Women who use antidepressants during pregnancy are not significantly increasing the risk of congenital malformations in their infants, according to results of a large prospective study Dr. A. Eri
Low Risk From Antidepressants During Pregnancy - low risk of birth defects - Brief Article
Women who use antidepressants during pregnancy are not significantly increasing the risk of congenital malformations in their infants, according to the results of a large prospective study. Dr. A
Antidepressant Therapy for Unexplained Symptoms and Symptom Syndromes
OBJECTIVE. To determine the efficacy of antidepressant therapy for unexplained symptoms or symptom syndromes. SEARCH STRATEGIES. We identified original ...

Home Contact Resources Exchange Links ebay