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Campath

Alemtuzumab (marketed as Campath or Campath-1H) is a monoclonal antibody used in the treatment of chronic lymphocytic leukemia (CLL) and T-cell lymphoma. more...

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Alemtuzumab targets CD52, a protein present on the surface of mature lymphocytes, but not on the stem cells from which these lymphocytes were derived. It is used as second line therapy for CLL. It was approved by the FDA for patients who have been treated with alkylating agents and who have failed fludarabine therapy.

A significant complication of therapy with alemtuzumab is that it significantly increses the risk for opportunistic infections, in particular, reactivation of cytomegalovirus.

Alemtuzumab is also used in some conditioning regimens for bone marrow transplantation.

History

The origins of alemtuzumab date back to Campath-1 which was derived from the mouse antibodies raised against human lymphocyte proteins (Hale et al 1983). The name "Campath" derives from the pathology department of Cambridge University. Initially, Campath-1 was unsuitable for therapy because patients reacted against the foreign mouse protein of the antibody. To circumvent this problem, Greg Winter and his colleagues humanised Campath-1, by extracting the hypervariable loops that had specificity for CD52 and grafted it onto a human antibody framework. This became known as Campath-1H and serves as the basis for alemtuzumab (Riechmann et al 1988).

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FDA Panel Backs Approval for Alemtuzumab.(Brief Article) : An article from: Family Practice News $5.95 Campath - 1 H: Emerging Frontline Therapy in Chronic Lymphocytic Leukemia $79.94
ILEX Oncology and Millennium submit biologics license application for CAMPATH.(Brief Article) : An article from: BIOTECH Patent News $5.95

Campath-1H for treating adult T-cell leukemia
This study is currently recruiting patients. Sponsored by National Cancer Institute (NCI). This study will examine the safety and effectiveness of Campath-1H for treating patients with adult T-
Campath-1H for treating adult T-cell leukemia - Clinical Trial Review - Brief Article
This study is currently recruiting patients. Sponsored by National Cancer Institute (NCI) Campath-lH (alemtuzumab) is approved by the Food and Drug ...
Stem cell transplant therapy with campath-1H for treating advanced mycosis fungoides and sezary syndrome - Clinical Trial Review - Brief Article
This study is currently recruiting patients. Sponsored by National Heart, Lung, and Blood Institute (NHLB1) This study will investigate the safety ...
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Campath Cleared for Marketing
The U.S. Food and Drug Administration (FDA) has cleared Campath (alemtuzumab), ahumanized monoclonal antibody, for marketing as a treatment for patients ...
ANTIBODIES: Biologics License Filed for Campath - monoclonal antibody for treatment of b-cell chronic lymphocytic leukemia - Brief Article
ILEX Oncology, Inc. (11550 Hwy. 10 W., Suite 100, San Antonio, TX 78230; Tel: 210/949-8200, Fax: 210/949-8210; Website: ilexoncology.com) and Millennium ...
Genzyme Corporation to Acquire Ilex Oncology Inc. for 32.82 Times Reveune
The Deal: Genzyme Corporation has agreed to acquire Ilex Oncology Inc. in a stock transaction valued at over $1 billion. Under the terms of the agreement, ...
Chronic Lymphocytic Leukemia - CLL - Patients Reach Five-Year Survival Milestone After Receiving Campath Therapy
Chronic Lymphocytic Leukemia (CLL) is the most prevalent form of adult leukemia. According to a recent study, 84 percent of patients with CLL in whom ...

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