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Carvedilol

Carvedilol (Coreg®) is a non-selective beta blocker indicated in the treatment of mild to moderate congestive heart failure (CHF). In addition to blocking both β1 and β2 type adrenoreceptors, carvedilol also displays α1-adrenergic antagonism as well, which confers the added benefit of reducing blood pressure through vasodilation. more...

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More importantly, carvedilol also has a minimal potential for "inverse agonism", or the deactivation of an activated receptor. This is important to CHF sufferers since inverse agonism causes negative chronotropic and inotropic effects. Essentially, carvedilol does not decrease the rate or strength of the hearts contractions as much as other beta blocking medications. CHF often significantly reduces how well the heart pumps, so any medication that further weakens the rate or strength of contractions is undesireable, therefore making carvedilol a better treatment than a beta blocker with stronger inverse agonism (such as propranolol).

On January 10, 2006, GlaxoSmithKline announced to pharmicists and physicans that there will be a limited availability of Coreg. This is due to documentation procedures with the manufacturer. It is not known when will Coreg will become broadly available. Patients who are taking Coreg should consult their healthcare professional about what actions they should take due to the shortage.

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Carvedilol study sparks debate on CHF therapy; 'clear difference' over metoprolol.(Cardiovascula r Medicine congestive heart failure) : An article from: Internal Medicine News $5.95 Enhances insulin sensitivity: carvedilol praised for its antidiabetic effects.(Cardiovascular Medicine) : An article from: Internal Medicine News $5.95
Carvedilol advantageous for diabetics with high BP: metabolic syndrome components improved. : An article from: Family Practice News $5.95

Carvedilol does not adversely affect glycemic control
Carvedilol improves components of the metabolic syndrome in patients with type 2 diabetes and hypertension, whereas metoprolol tartrate is associated ...
Role of carvedilol and digoxin in heart failure
In the treatment of heart failure and atrial fibrillation, digoxin has been a longstanding option. It is standard therapy in patients with heart failure ...
Left ventricular dysfunction: Carvedilol vs. Metoprolol - Tips from Other Journals
Early studies with selective beta blockers, such as bisoprolol and metoprolol XL, and with nonselective beta blockers, such as carvedilol, have demonstrated ...
Carvedilol or Metoprolol for chronic heart failure? - Tips from Other Journals
Chronic heart failure is a common and disabling condition for which current treatment guidelines recommend combination therapy with diuretics, angiotensin-converting ...
Antioxidant properties of carvedilol: Inhibition of lipid peroxidation, protein oxidation and superoxide generation
Oxidative stress has been suggested to be an etiological factor in cerebro- and cardiovascular disorders. We examined antioxidant activities of carvedilol, ...
Effect of carvedilol in patients with congestive heart failure - Tips from Other Journals
The Carvedilol Prospective Randomized Cumulative Survival (COPERNICUS) study evaluated the effect of carvedilol, an adrenergic blocker, on 2,289 patients ...
Carvedilol reduces the inappropriate increase of ventilation during exercise in heart failure patients - clinical investigations
Study objective: To evaluate the effects of [beta]-blockers on ventilation in heart failure patients. Indeed, [beta]-blockers ameliorate the clinical ...
Current research on carvedilol in heart failure - Letter to the Editor
Heart failure patients benefit from the addition of a [beta]-blocker to the standard heart failure regimen. (1) The question of which [beta]-blocker ...

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