Candesartan chemical structure
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Candesartan

Candesartan (kan-de-SAR-tan) belongs to the class of medicines called angiotensin II receptor antagonists. It is used to treat high blood pressure (hypertension) and is marketed under the brand name Atacand® (alternative name: Ratacand®) by AstraZeneca. more...

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High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.

Candesartan works by blocking the action of a substance in the body that causes blood vessels to tighten. As a result, candesartan relaxes blood vessels. This lowers blood pressure.

Side-effects

By decreasing aldosterone levels, candesartan and related drugs may cause hyperkalemia (high potassium levels in the blood). Supplements containing potassium, which are sometimes taken by patients with high blood pressure, are discouraged.

Some people taking candesartan report dizziness (occurs in 1 out of every 25 persons), blurry vision, lightheadedness, a sore throat or a runny nose. More serious side effects can be fainting, decreased sexual ability, jaundice, severe nausea, fatigue and chest pain.

Contraindications

It is contraindicated in pregnancy, especially in the last six months, preexistent hyperkalemia and a history of drug reactions to other AT II inhibitors.

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Replacement of valsartan and candesartan by telmisartan in hypertensive patients with type 2 diabetes: metabolic and antiatherogenic consequences.(Observation s) : An article from: Diabetes Care $5.95 Cardiac drug panel favors candesartan claim of superiority to losartan. (Results of Two, 8-Week Studies). : An article from: Internal Medicine News $5.95
CHARM study backs triple-drug therapy for CHF: undercuts existing guidelines. (Candesartan in Heart Failure: Assessment of Reduction in Mortality and Morbidity, ... : An article from: Internal Medicine News $5.95

Candesartan improves outcomes in chronic heart failure
Although outcomes in patients with chronic heart failure (CHF) have improved recently because of the increasingly widespread use of beta blockers and ...
Candesartan reduces cardiovascular death in CHF patients on ACE inhibitor
McMurray JJV, Ostergren J, Swedberg K, et al. Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function ...
Safety and Efficacy of Supramaximal Doses of Candesartan Cilexetil (160mg) In Reducing Proteinuria In Hypertensive Subjects With Renal Disease, The
Objective: To demonstrate the optimal doses of angiotensin receptor blockers for maximal inhibition of the Renin-Angiotensin System in order to achieve ...
Candesartan Improves Ejection Fraction And Decreases Atrial Natriuretic Peptide Levels In Diabetic Patients With Heart Failure
Purpose: Atrial natriuretic peptide (ANP) is elevated in CHF in response to chronic cardiac overload. Candesartan is a long acting angiotensin II (AII) ...
Randomised controlled trial of dual blockade of renin-angiotensin system in patients with hypertension, microalbuminuria, and non-insulin dependent diabetes:
A group of drugs called angiotensin II receptor blockers are as effective in lowering blood pressure as ACE inhibitors and may be used in combination with ...
Charm study results
New analysis of a major heart failure study demonstrates that patients treated with Atacand (candesartan) to lower blood pressure reported greater improvement ...
CASE PRESENTATIONS OF THE BROWN UNIVERSTY DEPARTMENT OF MEDICINE MIRIAM HOSPITAL MORBIDITY AND MORTALITY CONFERENCE: A CASE OF CARDIAC SARCOIDOSIS
Chief Complaint: Shortness of breath History of Present Illness: This 46-year-old African-American man, with a past medical history significant for end-stage ...
Pattern of prescription of non-steroidal antiinflammatory drugs in orthopaedic outpatient clinic of a north Indian tertiary care hospital
Byline: M. Gupta, S. Malhotra, S. Jain, A. Aggarwal, P. Pandhi Non-steroidal antiinflammatory drugs (NSAIDs) make up one of the largest groups of pharmaceutical agents used worldwide. In the past

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