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Chlorambucil

Chlorambucil (marketed as Leukeran) is a chemotherapy drug that has been mainly used in the treatment of chronic lymphocytic leukemia. It is a nitrogen mustard alkylating agent and can be given orally. more...

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In the past, it has been used for treating some types of non-Hodgkin lymphoma, Waldenström macroglobulinemia, polycythemia vera, trophoblastic neoplasms, ovarian carcinoma. It also has been used as an immunosuppressive drug for various autoimmune and inflammatory conditions, e.g. nephrotic syndrome. Its current use is mainly for CLL as it is well tolerated by most patients, though this has been primarily replaced by fludarabine.

Side effects include myelosuppression (anemia, neutropenia, thrombocytopenia).

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	Gale Encyclopedia of Cancer : Chlorambucil $2.30	The effects of chlorambucil in DBA/1J mice having RaVe lymphoblastic lymphoma (Kent State University honors papers : Department of Biological Sciences)

	The reactivity of chlorambucil with DNA


Chlorambucil-associated pneumonitis A patient developed an interstitial pneumonitis while receiving chlorambucil for a chronic lymphocytic leukemia (cumulative dose, 8,340 mg). Withdrawal ... From CHEST, 2/1/94 by Bruno Crestani

Chlorambucil Definition Chlorambucil (marketed under the brand name Leukeran) is a chemotherapy medicine used to treat cancer by interfering with the ... From Gale Encyclopedia of Cancer, by RPh. Nancy J. Beaulieu, BCOP

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Lymphocytic interstitial pneumonia and human immunodeficiency virus in the modern era INTRODUCTION: Lymphocytic interstitial pneumonitis (LIP) is classified under the idiopathic interstitial pneumonias. The incidence of LIP is uncommon, ... From CHEST, 10/1/05 by Michelle Cao

Hairy Cell Leukemia Variant With Features of Intrasinusoidal Bone Marrow Involvement Hairy cell leukemia variant (HCL-V) is a rare lymphoproliferative disorder. We report a case of HCL-V with an intrasinusoidal pattern of bone marrow involvement ... From Archives of Pathology & Laboratory Medicine, 3/1/05 by Ya-In, Charin

Polycythemia vera Polycythemia vera is a chronic myeloproliferative disorder characterized by increased red blood cell mass. The resultant hyperviscosity of the blood predisposes such patients to thrombosis. Polycyth From American Family Physician, 5/1/04 by Brian J. Stuart

chronic leukemias: Current and novel therapeutic approaches, The In 2003, an estimated 7,300 new cases of chronic lymphocytic leukemia (CLL) and 4,300 new cases of chronic myeloid leukemia (CML) will occur in the United ... From Medicine and Health Rhode Island, 8/1/03 by Rathore, Ritesh

Addressing anterior uveitis A review of the treatment strategies that successfully combat this condition. Anterior uveitis is the most common form of intraocular inflammation affecting ... From Optometric Management, 11/1/02 by Skorin, Leonid Jr

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