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Corticotropin

Adrenocorticotropic hormone (ACTH or corticotropin) is a polypeptide hormone synthesised (from POMC, pre-opiomelanocortin) and secreted from corticotropes in the anterior lobe of the pituitary gland in response to the hormone corticotropin-releasing hormone (CRH) released by the hypothalamus. It consists of 39 amino acids. more...

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ACTH acts through the stimulation of cell surface ACTH receptors, which are primarily located on the adrenocortical cells. ACTH stimulates the cortex of the adrenal gland and boosts the synthesis of corticosteroids, mainly glucocorticoids but also mineralcorticoids and sex steroids (androgens). Together with ACTH the hormones lipotropin, melanocyte-stimulating hormone (MSH), β-endorphin and met-enkephalin are also released. ACTH is also related to the circadian rhythm in many organisms.

The half-life of ACTH in human blood is about 10 minutes.

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Hormone wards off immune cells in womb - Science News of the week - corticotropin-releasing hormone - Brief Article A hormone known for its involvement in the brain's response to stress also plays a key role in shielding the developing embryo from its mother's immune ... From Science News, 10/20/01 by B. Harder

Maternal Depression and Risk for Postpartum Complications: Role of Prenatal Corticotropin-releasing Hormone and Interleukin-1 Receptor Antagonist - Statistical The pregnancies of 58 healthy adolescents (ages 13 to 19 years) were followed to examine links between symptoms of depression, corticotropin-releasing ... From Behavioral Medicine, 6/22/99 by Karen H. Schmeelk

role of corticotropin-releasing factor receptors in stress and anxiety, The The Role of Corticotropin-Releasing Factor Receptors in Stress and Anxiety1 SYNOPSIS. Corticotropin releasing factor (CRF) is a critical integrator of ... From Integrative and Comparative Biology, 6/1/02 by Bale, Tracy L

Stress and inflammation Molecular and biochemical bases for central nervous system-immune interactions include immune cytokines which activate immune function and also recruit ... From Townsend Letter for Doctors and Patients, 5/1/05 by Robert A. Anderson

Corticotropin-releasing hormone synthesizing neurons in the hypothalamic paraventricular nucleus of rats neonatally treated with monosodium glutamate can Neonatal administration of monosodium glutamate (MSG) produces pathological lesions in many brain regions. There are indications that MSG treatment could ... From Neurological Research, 12/1/99 by Kiss, Alexander

Baby blues - postpartum depression attributed to low levels of corticotropin-releasing hormone after placenta is gone - Brief Article Many new mothers feel depressed for weeks after giving birth. Physicians have vaguely attributed this malaise to exhaustion and to the demands of motherhood. From Discover, 12/1/95

Hormonal clock predicts premature births - maternal blood concentrations of corticotropin-releasing hormone predicts when birth will occur - Brief Article About 6 months into a pregnancy, some anxious parents-to-be stash a suitcase at the front door and nervously wait day and night for that moment when the ... From Science News, 4/29/95 by John Travis

Adrenocorticotropic hormone test Adrenocorticotropic hormone test (also known as an ACTH test or a corticotropin test) measures pituitary gland function. From Gale Encyclopedia of Medicine, 4/6/01 by Janis O. Flores

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