Chloroquine chemical structure
Find information on thousands of medical conditions and prescription drugs.

Chloroquine

Chloroquine is a commonly used form of medication against malaria. As it also mildly suppresses the immune system, it is used in some autoimmune disorders, such as rheumatoid arthritis. more...

Home
Diseases
Medicines
A
B
C
Cabergoline
Caduet
Cafergot
Caffeine
Calan
Calciparine
Calcitonin
Calcitriol
Calcium folinate
Campath
Camptosar
Camptosar
Cancidas
Candesartan
Cannabinol
Capecitabine
Capoten
Captohexal
Captopril
Carbachol
Carbadox
Carbamazepine
Carbatrol
Carbenicillin
Carbidopa
Carbimazole
Carboplatin
Cardinorm
Cardiolite
Cardizem
Cardura
Carfentanil
Carisoprodol
Carnitine
Carvedilol
Casodex
Cataflam
Catapres
Cathine
Cathinone
Caverject
Ceclor
Cefacetrile
Cefaclor
Cefaclor
Cefadroxil
Cefazolin
Cefepime
Cefixime
Cefotan
Cefotaxime
Cefotetan
Cefpodoxime
Cefprozil
Ceftazidime
Ceftriaxone
Ceftriaxone
Cefuroxime
Cefuroxime
Cefzil
Celebrex
Celexa
Cellcept
Cephalexin
Cerebyx
Cerivastatin
Cerumenex
Cetirizine
Cetrimide
Chenodeoxycholic acid
Chloralose
Chlorambucil
Chloramphenicol
Chlordiazepoxide
Chlorhexidine
Chloropyramine
Chloroquine
Chloroxylenol
Chlorphenamine
Chlorpromazine
Chlorpropamide
Chlorprothixene
Chlortalidone
Chlortetracycline
Cholac
Cholybar
Choriogonadotropin alfa
Chorionic gonadotropin
Chymotrypsin
Cialis
Ciclopirox
Cicloral
Ciclosporin
Cidofovir
Ciglitazone
Cilastatin
Cilostazol
Cimehexal
Cimetidine
Cinchophen
Cinnarizine
Cipro
Ciprofloxacin
Cisapride
Cisplatin
Citalopram
Citicoline
Cladribine
Clamoxyquine
Clarinex
Clarithromycin
Claritin
Clavulanic acid
Clemastine
Clenbuterol
Climara
Clindamycin
Clioquinol
Clobazam
Clobetasol
Clofazimine
Clomhexal
Clomid
Clomifene
Clomipramine
Clonazepam
Clonidine
Clopidogrel
Clotrimazole
Cloxacillin
Clozapine
Clozaril
Cocarboxylase
Cogentin
Colistin
Colyte
Combivent
Commit
Compazine
Concerta
Copaxone
Cordarone
Coreg
Corgard
Corticotropin
Cortisone
Cotinine
Cotrim
Coumadin
Cozaar
Crestor
Crospovidone
Cuprimine
Cyanocobalamin
Cyclessa
Cyclizine
Cyclobenzaprine
Cyclopentolate
Cyclophosphamide
Cyclopropane
Cylert
Cyproterone
Cystagon
Cysteine
Cytarabine
Cytotec
Cytovene
Isotretinoin
D
E
F
G
H
I
J
K
L
M
N
O
P
Q
R
S
T
U
V
W
X
Y
Z

Pharmacology

It has a very high volume of distribution, as it diffuses into the body's adipose tissue.

Mechanism of action

Inside the red blood cells, the parasite must degrade the hemoglobin for the acquisition of essential amino acids, which the parasite needs to survive and multiply inside the cell.

During this process, the parasite produces the toxic and soluble molecule heme. To avoid destruction by this molecule, the parasite aggregates heme to form hemozoin, an insoluble non-toxic molecule. Hemozoin formation is mediated by phospholipids as well as histidine-rich proteins Pfhrp-2 and Pfhrp-3.

Chloroquine interferes with binding of heme to histidine-rich proteins or lipids and prevents the formation of hemozoin, which in turn leaves heme in an uncrystallised form. This has a toxic effect to the parasite, and is therefore killed by this molecule.

The effectiveness of chloroquine against the parasite has declined as some resistant forms of the parasite can effectively neutralize the drug by developing a mechanism that drains chloroquine away from the key area, preventing heme from reaching the necessary concentration.

Against rheumatoid arthritis, it operates by inhibiting lymphocyte proliferation, phospholipase A, release of enzymes from lysosomes, release of reactive oxygen species from macrophages, and production of IL-1.

Read more at Wikipedia.org


[List your site here Free!]


Malaria: Drugs, Disease and Post-genomic Biology (Current Topics in Microbiology and Immunology) $111.10 CAR-5. Chloroquine cardiotoxicity: fatal but reversible.(Section on Cardiology) : An article from: Southern Medical Journal $5.95
Clofazimine rivals chloroquine for SLE lesions.(Rheumatology)(sy stemic lupus erythematosus) : An article from: Internal Medicine News $5.95

EFFECT OF CHLOROQUINE ON THE MURINE EXPERIMENTAL PARACOCCIDIOIDOMYCOSIS: MACROPHAGE ACTIVATION, CYTOKINES PRODUCTION AND TRANSFERRIN RECEPTOR EXPRESSION
Dias-Melicio, L. A.1; Calvi, S. A.2; Bordon, A. P.3; Acorci, M. J.4: Peraçoli, M. T. S.5; Scares. A. M. V. C.6 1,2,3,4,5,6 IB Unesp - Botucatu - Microbiologia ...
Efficacy of arteether in chloroquine resistant falciparum malaria in eastern India
Background & objectives: Morbidity and mortality due to falciparum malaria are increasing in many tropical areas. The situation is further complicated ...
ASSESSMENT OF CHLOROQUINE SINGLE DOSE TREATMENT OF MALARIA DUE TO Plasmodium vivax IN BRAZILIAN AMAZON
SUMMARY Malaria regions of ihc Amazon basin have been characterized by difficult access and non-compliance of the patients to treatment. In an attempt ...
In vitro evaluation of quinidine sensitivity in Brazilian Plasmodium falciparum isolates: Comparative analysis to quinine and chloroquine
SUMMARY Falciparum malaria represents a serious and an increasing world public health problem due to the acquired parasite's resistance to the most available ...
Chloroquine overdosage in infancy: a case report
Chloroquine Overdosage in Infancy: A Case Report Increased foreign travel and changes in the prevalence of malaria have made chloroquine more widely ...
Parkinson's protection? - research on use of chloroquine to retard symptoms of Parkinson's disease
Parkinson's protection? Low doses of a chemical known asMPTP cause brain damage and movement disorders that closely match Parkinson's disease in both ...
Who's to blame? The tsunami's aftermath
Galle, Sri Lanka THE last time I was here in Galle, England had just played a great cricket match against the Sri Lankans, the local economy was bustling, ...
In vitro evaluation of erythromycin in chloroquine resistant Brazilian P. falciparum freshly isolates: Modulating effect and antimalarial activity evidence
SUMMARY Erythromycin, a reversal agent in multidrug-resistant cancer, was assayed in chloroquine resistance modulation. The in vitro microtechnique for ...

Home Contact Resources Exchange Links ebay