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Cardiolite

Cardiolite® is the brand name of sestamibi, a radiopharmaceutical used in nuclear medicine imaging. It is also known as methoxyisobutylisonitrile or MIBI. The radioisotope attached to the sestamibi molecule is technetium-99m, forming 99Tcm-sestamibi (or Tc99m MIBI). more...

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Its main use is for imaging the myocardium (heart muscle). It is also used for imaging hyperparathyroidism of the parathyroid glands and for radioguided surgery of the parathyroid.

Cardiac imaging

When injected intravenously into a patient, it concentrates in the myocardium dependent on the myocardial blood flow. Single photon emission computed tomography (SPECT) imaging of the heart is performed using a gamma camera to detect the gamma rays emitted by the technetium-99m as it decays. Two sets of images are acquired. For one set, the patient is stressed either by exercising on a treadmill or by using a drug. The Tc99m MIBI is injected at peak stress and then imaging is performed. In the second set the Tc99m MIBI is injected whilst the patient is at rest and then imaged. The resulting two sets of images can be compared to distinguish ischaemic from infarcted areas of the myocardium. The imaging is also known as myocardial perfusion imaging (MPI).

Parathyroid imaging

In hyperparathyroidism, one or more of the four parathyroid glands have developed a benign tumour called an adenoma. The affected gland takes up Tc99m MIBI following an intravenous injection. The patient's neck is imaged with a gamma camera to show the tumour.

Radioguided surgery of the parathyroids

Following the administration of Tc99m MIBI it collects in overactive parathyroid glands. During surgery, the surgeon can use a probe sensitive to gamma rays to locate the overactive parathyroid before removing it.

Read more at Wikipedia.org


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New heart imaging products - Cardiolite and CardioTec
From FDA Consumer, 4/1/91

Two new heart imaging products, Cardiolite and CardioTec, are now available to help physicians identify and evaluate heart attacks and other coronary artery disease without using invasive procedures.

Cardiolite, approved Dec. 21, 1990, consists of a chemical called sestamibi that migrates and binds to undamaged heart muscle. The sestamibi is tagged with technetium Tc99m, a radioisotope that allows a gamma camera to image the heart. The product was developed by researchers at Du Pont Merck Co., Harvard University, and the Massachusetts Institute of Technology.

When Cardiolite is injected into the bloodstream, doctors can trace its flow through the heart to assess damage from a heart attack and evaluate the heart's pumping action as well. Cardiolite allows imaging of the heart up to four hours after injection. This is a much longer period than was possible using thallium TI 201, a widely used cardiac imaging isotope.

CardioTec, approved Dec. 19, 1990, consists of a chemical called teboroxime, which, like sestamibi, is radio-labeled with technetium Tc 99m. It is used to evaluate heart attacks as well as ischemic heart disease (partial obstruction of coronary blood flow) and is measured using stress-rest techniques.

According to the manufacturer, a typical stress-rest test can be completed within one-and-a-half to two hours using CardioTec, whereas a thallium study usually requires four or more hours to complete.

Cardiolite is marketed by the Du Pont Merck Pharmaceutical Co., Wilmington. CardioTec is sold by BristolMyers Squibb Co., Princeton, N.J.

COPYRIGHT 1991 U.S. Government Printing Office
COPYRIGHT 2004 Gale Group

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