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Cardiolite

Cardiolite® is the brand name of sestamibi, a radiopharmaceutical used in nuclear medicine imaging. It is also known as methoxyisobutylisonitrile or MIBI. The radioisotope attached to the sestamibi molecule is technetium-99m, forming 99Tcm-sestamibi (or Tc99m MIBI). more...

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Its main use is for imaging the myocardium (heart muscle). It is also used for imaging hyperparathyroidism of the parathyroid glands and for radioguided surgery of the parathyroid.

Cardiac imaging

When injected intravenously into a patient, it concentrates in the myocardium dependent on the myocardial blood flow. Single photon emission computed tomography (SPECT) imaging of the heart is performed using a gamma camera to detect the gamma rays emitted by the technetium-99m as it decays. Two sets of images are acquired. For one set, the patient is stressed either by exercising on a treadmill or by using a drug. The Tc99m MIBI is injected at peak stress and then imaging is performed. In the second set the Tc99m MIBI is injected whilst the patient is at rest and then imaged. The resulting two sets of images can be compared to distinguish ischaemic from infarcted areas of the myocardium. The imaging is also known as myocardial perfusion imaging (MPI).

Parathyroid imaging

In hyperparathyroidism, one or more of the four parathyroid glands have developed a benign tumour called an adenoma. The affected gland takes up Tc99m MIBI following an intravenous injection. The patient's neck is imaged with a gamma camera to show the tumour.

Radioguided surgery of the parathyroids

Following the administration of Tc99m MIBI it collects in overactive parathyroid glands. During surgery, the surgeon can use a probe sensitive to gamma rays to locate the overactive parathyroid before removing it.

Read more at Wikipedia.org


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Easy on the hearth - Health & Medicine - Brief Article
From American Fitness, 11/1/01

More than 12 million Americans suffer from coronary artery disease, a that often entails costly, invasive procedures, such as catheters inserted into blood vessels and x-ray material injected into the arterial highway.

According to new research presented by the American College of Cardiology (ACC), the Cardiolite[R] heart-imaging procedure can evaluate function (the heart's pumping ability), perfusion (the amount of blood flowing to the heart) and can identify the presence or absence of heart disease.

"By utilizing nuclear cardiology testing, in advance of more aggressive diagnostic tests, we can both avoid exposing patients to unnecessary surgical risks and medical expenses," says Howard Lewin, M.D. "This study shows that Cardiolite[R] may spare some patients from these risks and the discomfort of cardiac catheterization by identifying situations when it is not needed."

For more information on Cardiolite[R], call (800) 362-2668 or visit www.cardiolite.com.

COPYRIGHT 2001 Aerobics and Fitness Association of America
COPYRIGHT 2001 Gale Group

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