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Cefotetan

Cefotetan is an injectable antibiotic of the cephamycin type for prophylaxis and treatment of bacterial infections. It is a second generation cephalosporin that has some anaerobe converage.

Cefotetan was developed by Yamanouchi. It is marketed outside Japan by AstraZeneca with the brand names Apatef and Cefotan.

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Extended-spectrum beta-lactamases producing klebsiella pneumoniae infection, risk factors, antibiotic use and background
From CHEST, 10/1/05 by Frew H. Gebreab

PURPOSE: The development of multi-drug resistant bacterial infections is a serious problem in many hospitals. This study was conducted to identify the risk factors mad antibiotic usage in medical intensive care and pulmonary step down patients who developed ESBL-KP infections at New York Methodist Hospital.

METHODS: Medical records of 47 patients who developed 50 ESBL-KP infections between January to December 2004 were reviewed. Data collection included demographics, admission diagnosis,and risk factors for development of ESBL-KP infections.

RESULTS: Of 47 patients; 74.5% (n=35) were females, and 25.5% (n= 12) were males in which 59.6% of them were admitted from home while the remaining 40.4% came from nursing facilities. Patients were admitted for sepsis (27.6%), acute respiratory failure (14.8%), pneumonia (17%), urinary tract infections (12.8%), acute renal failure (12.8 %), acute abdomen (8.5%), hepatic encephalopathy (4.3%) and malignancy (2.1%). All patients were treated with at least one broad spectrum antibiotic (Figure 1) for a mean duration of 14.5 days prior to the development of ESBL-KP infections. Ninety-eight percent of patients had at least 1 invasive procedure (Figure 2). The study identified that out of fifty ESBL-KP isolates; 52% (n=26) resulted in urinary tract, 24% (n=12) respiratory tract, 22% (n=11) blood stream, and 2% (n= 1) surgical wound infection. Eighty four percent of isolates were sensitive to aminoglycosides whereas only 46% were sensitive to a carbapenem (Figure 3). The mean length of stay of ESBL-KP infections 46 days and all cause mortality was 32%.

CONCLUSION: 1. There was no community acquired ESBL-KP infections. 2. Majority of ESBL-KP infections were sensitive to aminoglycosides. 3. Urinary tract was the most common site of infection 4. Majority of patients had invasive procedures and all were treated with broad spectrum antibiotics prior to ESBL-KP isolation.

CLINICAL IMPLICATIONS: Identification of possible risk factors for development infection with multi-drug resistant pathogen like ESBL-KP will be helpful in prevention ,early detection and treatment of such infection.

Frew H. Gebreab MD * Nasser Saad RPh Liziamma George MD Teena Abraham PharmD Imran Aurangzeb MD Elias Ashame MD Kelly Marion RN Suhail Raoof MD New York Methodist Hospital, Brooklyn, NY

COPYRIGHT 2005 American College of Chest Physicians
COPYRIGHT 2005 Gale Group

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