Tadalafil structure
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Cialis

Tadalafil is a drug used to treat male erectile dysfunction (impotence). It was developed by the biotechnology firm ICOS and marketed worldwide by Eli Lilly and Company under the brand name Cialis. It works by inhibiting an enzyme known as PDE5. Due to its 36-hour effect it is also known as the "Weekend Pill". In the United States, tadalafil has Food and Drug Administration approval and became available in December, 2003. more...

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Chemical information

The empirical formula for tadalafil is C22H19N3O4, and its official organic name is (6R,12aR)-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a- hexahydro-2-methyl-pyrazinopyridoindole-1,4-dione. The molecular weight is 389.41. The tablets are yellow, film-coated, and almond-shaped, and are produced in 5, 10, or 20mg doses. A 20mg dose of Tadalafil is comparable to a 100mg dose of sildenafil (Viagra). The MSDS for this compound can be found here:

Side effects

The most common side effects when using tadalafil are headache, indigestion, back pain, muscle aches, flushing, and stuffy or runny nose. These side effects usually go away after a few hours. Patients who get back pain and muscle aches usually get it 12 to 24 hours after taking the drug, and the symptom usually goes away after 48 hours.

In May 2005, the U.S. Food and Drug Administration found that tadalafil (along with other PDE5 inhibitors) could lead to vision impairment in certain patient groups, e.g. diabetics. An investigation is currently ongoing.

Drug interactions

Organic nitrates

Since PDE5 inhibitors such as tadalafil may cause transiently low blood pressure (hypotension), organic nitrates should not be taken for at least 48 hours after taking the last dose of tadalafil. Using organic nitrates within this timeframe may increase the risk of life-threatening hypotension. Since people who have taken tadalafil within the past 48 hours cannot take organic nitrates to relieve angina, these patients should seek immediate medical attention if they experience anginal chest pain . In the event of a medical emergency, paramedics and medical personnel should be notified of any recent doses of tadalafil.

Marketing

In the United States, Eli Lilly has a multiyear agreement to promote tadalafil (Cialis) with professional golf's PGA TOUR.

Trivia

  • The word "specialist" is frequently caught by primitive spam email blockers because it contains the word "cialis."

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Drugs cheaper in Canada except for Viagra, Cialis and Levitra
From Healthfacts, 11/1/05

To save money, Americans have been buying prescription drugs from Canada over the Internet for years. A team of Canadian researchers decided not only to test the perception that the same drugs purchased in Canada are, in fact, cheaper but they also set out to quantify the savings. Their findings, published recently in Annals of Internal Medicine, clearly favor shopping at the Canadian Internet pharmacies.

The researchers led by Bradley S. Quon, MD, compared prices at 12 Internet pharmacies in Canada with those at three major online drug chain pharmacies in the U.S. (CVS, Rite Aid, and Walgreen). The 44 brand-name drugs in this study are the medications Americans most often purchase from Canadian Internet pharmacies.

Quon and colleagues found that 41 of the 44 brandname drugs were less expensive in Canada, often substantially so. Only three drugs were more expensive in Canada--the erectile dysfunction drugs Viagra, Levitra, and Cialis. The biggest yearly savings applied to the antipsychotic drug, Zyprexa ($1,159), the diabetes drug, Actos ($852), and the heartburn drug, Nexium ($772).

Other drugs that were considerably less expensive in the Canadian Online pharmacies include the heartburn drugs Prevacid and Prilosec (sold under the brand name Losec in Canada); the antidepressants Celexa, Prozac, Wellbutrin, and Effexor; the antihistamine Zyrtec; and the cholesterol-lowering drugs Lipitor and Pravachol.

American law prohibits drug importation, but individuals are permitted to import up to 90 days worth of medications for personal use, according to Quon and colleagues. They note that Canadian pharmacies have taken advantage of this policy by selling up to a 90-day supply by mail order to Americans.

The Canadian Internet pharmacies were selected for this study on the basis of listings from Pharmacychecker.com. This Web site, Quon and colleagues identified as "a price comparison tool designed to assist consumers in obtaining their prescription medications at the lowest possible prices." The three American pharmacies were chosen because they are the largest drug stores based on sales revenue. (See next page for all Web addresses.)

Reminder:

In 2003, the Bush administration and its Congressional allies passed the Medicare Modernization Act. Despite the disingenuous name, this legislation forbids the federal government from negotiating discount prices for the drugs taken by people on Medicare. Canada--like most other industrialized nations --negotiates discounts with each pharmaceutical company.

COPYRIGHT 2005 Center for Medical Consumers, Inc.
COPYRIGHT 2005 Gale Group

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