Tadalafil structure
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Cialis

Tadalafil is a drug used to treat male erectile dysfunction (impotence). It was developed by the biotechnology firm ICOS and marketed worldwide by Eli Lilly and Company under the brand name Cialis. It works by inhibiting an enzyme known as PDE5. Due to its 36-hour effect it is also known as the "Weekend Pill". In the United States, tadalafil has Food and Drug Administration approval and became available in December, 2003. more...

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Chemical information

The empirical formula for tadalafil is C22H19N3O4, and its official organic name is (6R,12aR)-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a- hexahydro-2-methyl-pyrazinopyridoindole-1,4-dione. The molecular weight is 389.41. The tablets are yellow, film-coated, and almond-shaped, and are produced in 5, 10, or 20mg doses. A 20mg dose of Tadalafil is comparable to a 100mg dose of sildenafil (Viagra). The MSDS for this compound can be found here:

Side effects

The most common side effects when using tadalafil are headache, indigestion, back pain, muscle aches, flushing, and stuffy or runny nose. These side effects usually go away after a few hours. Patients who get back pain and muscle aches usually get it 12 to 24 hours after taking the drug, and the symptom usually goes away after 48 hours.

In May 2005, the U.S. Food and Drug Administration found that tadalafil (along with other PDE5 inhibitors) could lead to vision impairment in certain patient groups, e.g. diabetics. An investigation is currently ongoing.

Drug interactions

Organic nitrates

Since PDE5 inhibitors such as tadalafil may cause transiently low blood pressure (hypotension), organic nitrates should not be taken for at least 48 hours after taking the last dose of tadalafil. Using organic nitrates within this timeframe may increase the risk of life-threatening hypotension. Since people who have taken tadalafil within the past 48 hours cannot take organic nitrates to relieve angina, these patients should seek immediate medical attention if they experience anginal chest pain . In the event of a medical emergency, paramedics and medical personnel should be notified of any recent doses of tadalafil.

Marketing

In the United States, Eli Lilly has a multiyear agreement to promote tadalafil (Cialis) with professional golf's PGA TOUR.

Trivia

  • The word "specialist" is frequently caught by primitive spam email blockers because it contains the word "cialis."

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Rise of the Kasai
From Electronic Gaming Monthly, 3/1/05

Sony’s 2000 brawler The Mark of Kri achieved cult status by getting three things right—an innovative analog-stick fighting system, a pack of intricate puzzles, and a wild visual style that blends Disney charm with copious gore. Kri fans can expect more of all three in Kasai, its sequel. “When we originally designed The Mark of Kri, we were excited by the [graphical] juxtaposition,” explains Producer Jay Beard. “The reaction to this look was overwhelmingly positive, causing us to look at the sequel with a little more confidence in terms of what we could get away with.”

As Rise of the Kasai proves, what Beard and his team at BottleRocket gets away with is another fine mix of action and stealth gameplay. Rau, the silent, lumbering hero of the original, is back...well, sort of. Actually, just like God of War’s Kratos, our hero meets his untimely end at the game’s outset. You’ll still play as Rau in flashback levels, but much of the game stars his friends and family (see sidebar). Each of the four playable characters has several melee weapons, as well as a special “remote view” ability—Rau can use his bird Kuzo to scout out ahead, while Tati has the rather unalluring ability to look through the eyes of corpses lying on the road.

With all these husky fighters at your disposal, Kasai rewards teamwork. Each stage is tackled with two characters; you control one directly while helping your computer-controlled partner take on enemies. (Sadly, Sony scrapped a planned online mode.) Knowing your mate’s personality will be just as important as knowing his abilities: “You could be attempting to sneak around,” explains Beard, “when Tati comes charging in, ax drawn, blows the scenario, and gets you into a fight. So when playing as Rau, part of the gameplay is to anticipate Tati’s poor judgment and play accordingly.”

This cooperative aspect adds a new angle to a game already laden with originality. Like Kri before it, Kasai isn’t just a bash-em-up or a Renaissance-fair version of Splinter Cell—it’s a game that combines bits from all these genres to create something new. “Every level responds differently to how you want to play it,” says Beard. “It isn’t about a type of combat; it’s about all aspects of combat.”

Platform: PlayStation 2

Publisher: Sony CEA

Developer: BottleRocket

Release: March 2005

Meet the Family

Rau’s brought the family over for the sequel. Be nice.

Tati

Rau’s little sister (still a child in the last game) is now a 20-year-old ball of pissed-off, knife-wielding girl power. Rock on.

Baumusu

Rau and Tati’s adoptive father, Baumusu is among the last of the Rakus, an ancient order of gruff, smelly warriors.

Griz

This calm Zen-master type (the leader of the Rakus) is surprisingly spry for such a crabby old dude. Cialis, maybe?P

Copyright © 2005 Ziff Davis Media Inc. All Rights Reserved. Originally appearing in Electronic Gaming Monthly.

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