Chemical structure of cidofovir
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Cidofovir

Cidofovir is an injectable antiviral medication for the treatment of cytomegalovirus (CMV) retinitis in patients with AIDS. It suppresses CMV replication by selective inhibition of viral DNA synthesis. more...

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Cidofovir demonstrated a statistically significant effect in delaying the progression of CMV retinitis lesions in newly diagnosed patients, as well as in previously treated patients who had failed other therapies. Maintenance therapy with cidofovir involves an infusion only once every two weeks, making it a convenient treatment option. Because dosing is relatively infrequent, a permanent catheter is not necessary for infusions.

Cidofovir has also been investigated as a treatment for progressive multifocal leukoencephalopathy, but as of 2005 studies are inconclusive.

Cidofovir was developed by Gilead Sciences and is marketed with the brand name Vistide by Gilead in the USA, and by Pfizer elsewhere.


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Visualization of the hyoid bone with laryngeal endoscopy
From Ear, Nose & Throat Journal, 1/1/05 by Adam D. Rubin

A 51-year-old businessman with a history of recurrent laryngeal papillomatosis presented to our office for an evaluation. He had undergone numerous excisions and photodynamic therapy by other otolaryngologists. He was seeking an additional opinion and wished to be considered for cidofovir injection. Since his last surgery, his hoarseness had increased, but he denied any dyspnea or dysphagia.

Stroboscopic examination detected bilateral papillomatosis of the true and false vocal folds. The patient was treated with cold excision and cidofovir injection. At follow-up examinations over a period of years, he remained free of disease. However, at his most recent evaluation, we detected a "mass" on the posterior pharyngeal wall (figure). This mass turned out to be the hyoid bone, which had protruded into the pharyngeal mucosa. This finding is a normal variant and should not be mistaken for pathology.

[FIGURE OMITTED]

COPYRIGHT 2005 Medquest Communications, LLC
COPYRIGHT 2005 Gale Group

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