Chemical structure of desloratadine.3D Model of desloratadine.
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Clarinex

Desloratadine is a drug used to treat allergies. It is marketed under several trade names such as NeoClarityn®, Claramax®, Clarinex® and Aerius®. It is an active metabolite of loratadine, which is also on the market. more...

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Available forms

Desloratadine is available as tablets and oral suspension.

Mechanism of action

Desloratadine is a tricyclic antihistamine, which has a selective and peripheral H1-antagonist action. It has a long-lasting effect and does not cause drowsiness because it does not readily enter the central nervous system. It is 10-20 times more potent as an antihistamine than loratadine.

Pharmacokinetics

Desloratadine is rapidly absorbed from the gastro-intestinal tract. Desloratadine is moderately bound to plasma proteins (85%). The half-life of desloratadine is on average 28 hours. About 40% is excreted as conjugated metabolites into the urine and similar amount into the feces. Traces of unmetabolised desloratadine can be found in the urine.

Side effects

Most common side-effects are fatigue, drowsiness, dry mouth, headache, and gastrointestinal disturbances.

Desloratadine vs. loratadine

A November 2003 article published in the journal American Family Physician about the safety, tolerability, effectiveness, price, and simplicity of desloratadine concluded the following:

Desloratadine is similar in effectiveness to fexofenadine and would be expected to produce results similar to loratadine and other nonsedating antihistamines. There is no clinical advantage to switching a patient from loratadine to desloratadine. However, it may be an option for patients whose medical insurance no longer covers loratadine if the co-pay is less than the cost of the over-the-counter product.

Read more at Wikipedia.org


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Clarinex-D 24 Hour extended release tablets approved by the FDA
From Journal of Drugs in Dermatology, 7/1/05

The FDA has recently approved Clarinex-D 24 Hour (desloratadine 5 mg and pseudoephedrine sulfate USP 240 mg) extended release tablets to treat nasal and non-nasal symptoms of seasonal allergic rhinitis in patients 12 years of age or older. There were two 2-week trials, both demonstrating significantly greater efficacy of Clarinex-D 24 Hour for allergic rhinitis, compared to desloratidine or pseudoephedrine, which led to FDA approval of this combination 24-hour medication. Clarinex-D 24 Hour also provided significantly greater relief from nasal congestion compared to desloratadine.

Clarinex-D 24 Hour uses a Gel Control mechanism which provides controlled release of the pseudoephedrine throughout the day thus allowing patients to wake up symptom free.

Clarinex-D 24 Hour should be avoided in patients with narrow angle glaucoma, severe hypertension or heart disease, urinary retention, and in patients receiving therapy with monoamine oxidase (MAO) inhibitors. It should be used in caution with impaired hepatic function or renal function, hypertension, heart disease, hyperthyroidism, diabetes mellitus, or prostate hyperplasia.

The side effect profile of Clarinex-D 24 Hour is similar to that of desloratidine alone; however, incidence of anticholinergic symptoms such as dry mouth may be increased. Additionally adverse effects secondary to pseudoephedrine including cardiac arrhythmia and central nervous system insult must be taken into consideration.

COPYRIGHT 2005 Journal of Drugs in Dermatology, Inc.
COPYRIGHT 2005 Gale Group

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