Chemical structure of desloratadine.3D Model of desloratadine.
Find information on thousands of medical conditions and prescription drugs.

Clarinex

Desloratadine is a drug used to treat allergies. It is marketed under several trade names such as NeoClarityn®, Claramax®, Clarinex® and Aerius®. It is an active metabolite of loratadine, which is also on the market. more...

Home
Diseases
Medicines
A
B
C
Cabergoline
Caduet
Cafergot
Caffeine
Calan
Calciparine
Calcitonin
Calcitriol
Calcium folinate
Campath
Camptosar
Camptosar
Cancidas
Candesartan
Cannabinol
Capecitabine
Capoten
Captohexal
Captopril
Carbachol
Carbadox
Carbamazepine
Carbatrol
Carbenicillin
Carbidopa
Carbimazole
Carboplatin
Cardinorm
Cardiolite
Cardizem
Cardura
Carfentanil
Carisoprodol
Carnitine
Carvedilol
Casodex
Cataflam
Catapres
Cathine
Cathinone
Caverject
Ceclor
Cefacetrile
Cefaclor
Cefaclor
Cefadroxil
Cefazolin
Cefepime
Cefixime
Cefotan
Cefotaxime
Cefotetan
Cefpodoxime
Cefprozil
Ceftazidime
Ceftriaxone
Ceftriaxone
Cefuroxime
Cefuroxime
Cefzil
Celebrex
Celexa
Cellcept
Cephalexin
Cerebyx
Cerivastatin
Cerumenex
Cetirizine
Cetrimide
Chenodeoxycholic acid
Chloralose
Chlorambucil
Chloramphenicol
Chlordiazepoxide
Chlorhexidine
Chloropyramine
Chloroquine
Chloroxylenol
Chlorphenamine
Chlorpromazine
Chlorpropamide
Chlorprothixene
Chlortalidone
Chlortetracycline
Cholac
Cholybar
Choriogonadotropin alfa
Chorionic gonadotropin
Chymotrypsin
Cialis
Ciclopirox
Cicloral
Ciclosporin
Cidofovir
Ciglitazone
Cilastatin
Cilostazol
Cimehexal
Cimetidine
Cinchophen
Cinnarizine
Cipro
Ciprofloxacin
Cisapride
Cisplatin
Citalopram
Citicoline
Cladribine
Clamoxyquine
Clarinex
Clarithromycin
Claritin
Clavulanic acid
Clemastine
Clenbuterol
Climara
Clindamycin
Clioquinol
Clobazam
Clobetasol
Clofazimine
Clomhexal
Clomid
Clomifene
Clomipramine
Clonazepam
Clonidine
Clopidogrel
Clotrimazole
Cloxacillin
Clozapine
Clozaril
Cocarboxylase
Cogentin
Colistin
Colyte
Combivent
Commit
Compazine
Concerta
Copaxone
Cordarone
Coreg
Corgard
Corticotropin
Cortisone
Cotinine
Cotrim
Coumadin
Cozaar
Crestor
Crospovidone
Cuprimine
Cyanocobalamin
Cyclessa
Cyclizine
Cyclobenzaprine
Cyclopentolate
Cyclophosphamide
Cyclopropane
Cylert
Cyproterone
Cystagon
Cysteine
Cytarabine
Cytotec
Cytovene
Isotretinoin
D
E
F
G
H
I
J
K
L
M
N
O
P
Q
R
S
T
U
V
W
X
Y
Z

Available forms

Desloratadine is available as tablets and oral suspension.

Mechanism of action

Desloratadine is a tricyclic antihistamine, which has a selective and peripheral H1-antagonist action. It has a long-lasting effect and does not cause drowsiness because it does not readily enter the central nervous system. It is 10-20 times more potent as an antihistamine than loratadine.

Pharmacokinetics

Desloratadine is rapidly absorbed from the gastro-intestinal tract. Desloratadine is moderately bound to plasma proteins (85%). The half-life of desloratadine is on average 28 hours. About 40% is excreted as conjugated metabolites into the urine and similar amount into the feces. Traces of unmetabolised desloratadine can be found in the urine.

Side effects

Most common side-effects are fatigue, drowsiness, dry mouth, headache, and gastrointestinal disturbances.

Desloratadine vs. loratadine

A November 2003 article published in the journal American Family Physician about the safety, tolerability, effectiveness, price, and simplicity of desloratadine concluded the following:

Desloratadine is similar in effectiveness to fexofenadine and would be expected to produce results similar to loratadine and other nonsedating antihistamines. There is no clinical advantage to switching a patient from loratadine to desloratadine. However, it may be an option for patients whose medical insurance no longer covers loratadine if the co-pay is less than the cost of the over-the-counter product.

Read more at Wikipedia.org


[List your site here Free!]


New & Approved: Clarinex Procleix HIV-1/HCV assay - Primary Care
From OB/GYN News, 4/15/02 by Elizabeth Mechcatie

Clarinex

(desloratadine, Schering-Plough)

A long-acting tricyclic histamine antagonist for the relief of nasal and nonnasal symptoms of perennial and seasonal allergic rhinitis in people aged 12 and older. Also approved for the symptomatic relief of pruritus and reduction of hives in patients with chronic idiopathic urticaria in the same age group. This is an active metabolite of loratadine (Claritin), which--with the exception of perennial allergic rhinitis--is approved for the same indications in people aged 2 years and older.

* Recommended Dosage: 5 mg once a day. A starting dose of 5 mg every other day is recommended for patients with liver or renal impairment.

* Special Considerations: Like Claritin, Clarinex appears to be a benign medication with a high therapeutic index, said Dr. Eli Meltzer, chair of the American Academy of Allergy, Asthma, and Immunology's pharmacotherapeutics committee. Absorption not affected by food, including grapefruit juice; no interactions with erythromycin or ketoconazole have been observed.

* Comment: In placebo-controlled studies, Clarinex was found to significantly reduce symptoms of seasonal and perennial allergic rhinitis. In two 4-week studies of almost 1,000 patients aged 15-75 with asthma and seasonal allergic rhinitis, those treated with Clarinex had improvements in rhinitis symptoms, with no decrease in pulmonary function. This "supports the safety" of Clarinex in adults with both conditions, according to the drug's labeling. In two placebo-controlled studies of patients with chronic idiopathic urticaria, Clarinex reduced the severity of pruritus, the number of hives, and size of the largest hive, according to the labeling.

There are no approved claims for its comparability with other antihistamines, including Claritin, and in announcing the product's approval, the company did not make any claims about its superiority.

Clarinex was not compared directly with Claritin or other antihistamines in trials, but in vivo and in vitro evidence shows that Clarinex binds better to [H.sub.1] receptors than Claritin, said Dr. Meltzer, an investigator in some of the trials. He is codirector of the Allergy and Asthma Medical Group and Research Center in San Diego.

Clarinex "is a very good [H.sub.1] receptor antagonist and has a long half-life, so it can clearly be used once a day," he said. Most of the other available antihistamines effectively treat perennial allergic rhinitis, although they are not approved for this indication, he noted. Zyrtec (cetirizine) also is approved for perennial allergic rhinitis.

Clarinex "is a little less expensive" than Claritin, said Dr. Meltzer, who is a consultant to Schering-Plough and is on the company's speakers' bureau. Studies of Clarinex in patients younger than age 12 are underway, according to the company.

Procleix HIV-1/HCV Assay

(Gen-Probe and Chiron)

A nucleic acid amplification test (NAT) system for screening whole-blood donors for HIV-1 and hepatitis C virus (HCV) simultaneously The system detects these viruses at the very early stages of infection before antibodies or viral antigens appear. This is the first nucleic acid test system approved by the Food and Drug Administration for use in screening donated blood and blood components intended for transfusions; other tests are being developed.

* Comment: The use of this test "is expected to further ensure the safety of whole blood and blood components, including red cells, fresh plasma, and platelets, by permitting earlier detection of HIV and HCV in donors," the FDA said in a statement. Because the system detects viral genes, instead of antibodies or antigens, these viruses can be detected earlier in the course of infection, the statement noted.

Currently, blood and plasma donors are tested for HCV antibodies, and for HIV antibodies and antigens, but a window period remains in which a donor can be infected with these viruses but have negative screening tests. In its statement, the FDA said that the use of this system to detect HCV reduces this window by about 57 days, from an average of 82 days to 25 days. For HIV-1, the use of this system reduces the window to about 12 days, compared with about 16 days with antigen testing. (The average window period for HIV-1 with antibody testing is 22 days.)

In U.S. studies of the system, 7 HIV-1-positive and 88 HCV-positive donations were detected in more than 20 million donations tested, according to Chiron.

COPYRIGHT 2002 International Medical News Group
COPYRIGHT 2002 Gale Group

Return to Clarinex
Home Contact Resources Exchange Links ebay