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Cozaar

Losartan is a drug used to treat high blood pressure (hypertension) and has been examined for congestive heart failure and diabetic nephropathy. It is marketed as Cozaar® by Merck Sharp and Dohme and as Hyzaar® in combination with the thiazide diuretic hydrochlorothiazide (HCT). more...

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Losartan was the first member of the recently introduced class of angiotensin II receptor antagonists. It blocks the action of the peptide hormone angiotensin on its receptors, decreasing arterial vascular tone and production of aldosterone.

Indications:

  • Essential hypertension
  • Hypertension with left ventricular hypertrophy for lowering the risk of cardiovascular morbidity and mortality
  • Diabetes mellitus type 2 with proteinuria for slowing down the progression of kidney disease

Because of proven effectivity and lower costs, the first choice of drug for essential hypertension is a thiazide or beta blocker. The primary use of losartan is for proven stroke prevention. A clinical trial called LIFE demonstrated that losartan works significantly better than atenolol in preventing stroke (PMID 11937178).

Adverse effects

Adverse effects of Losartan include:

  • Dizziness
  • Hyperkalemia

Overdose

An overdose of losartan will result in hypotension and tachycardia.

Availability

In most countries, this medication is available only by prescription.

Read more at Wikipedia.org


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From Shape, 10/1/04

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The Breakfast Club

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Can't find time to exercise? You've got choices. Opt for a morning workout--you'll fit in fitness and gain energy for the day. If you still can't swing it, make the choice to exercise whenever you can--take the stairs instead of the elevator, or get off the bus a few stops early and walk the rest of the way to work.

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Yasmin[R] is a low-dose birth control pill that is more than 99% effective at preventing pregnancy. Yasmin can help:

* Give you shorter, lighter periods

* Reduce cramps

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Talk to your healthcare provider about Yasmin and see the important safety information on the opposite page.

Learn more at www.yasmin.com

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Important safety information about Yasmin:

What makes Yasmin[R] different from other birth control pills?

It contains a different kind of progestin which may increase potassium. For healthy women this is not a problem.

How can you be sure Yasmin is safe for you?

Consult your doctor. You should not take Yasmin if you have kidney, liver or adrenal disease because this could cause serious heart and health problems.

What drugs could interfere with Yasmin?

Potassium-increasing drugs. Tell your doctor if you are on daily, long-term treatment for a chronic condition with any of the following: NSAIDs-ibuprofen (Motrin[R], Advil[R]), naproxen (Naprosyn[R], Aleve[R], and others) when taken long-term and daily for arthritis or other diseases or conditions, potassium-sparing diuretics (spironolactone and others), potassium supplementation, ACE inhibitors (Capoten[R], Vasotec[R], Zestril[R], and others). Angiotensin-II receptor antagonists (Cozaar[R], Diovan[R], Avapro[R], and others), and Heparin. Women who take any of the preceding drugs every day should have their potassium level checked in the first month of taking Yasmin.

What are the risks involved with taking any oral contraceptive (OC)?

OCs can be associated with increased risks of several serious side effects, and do not protect against HIV infection or other STDs. Women, particularly those 35 and over, are strongly advised not to smoke due to the risk of serious cardiovascular side effects.

COPYRIGHT 2004 Weider Publications
COPYRIGHT 2004 Gale Group

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